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Titolo:
The ErbB receptor tyrosine family as signal integrators
Autore:
Hynes, NE; Horsch, K; Olayioye, MA; Badache, A;
Indirizzi:
Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4002 002 Basel, Switzerland
Titolo Testata:
ENDOCRINE-RELATED CANCER
fascicolo: 3, volume: 8, anno: 2001,
pagine: 151 - 159
SICI:
1351-0088(200109)8:3<151:TERTFA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; NEU DIFFERENTIATION FACTOR; MAMMARY EPITHELIAL-CELLS; BREAST-CANCER CELLS; EGF RECEPTOR; NEUREGULIN RECEPTOR; CARDIAC DEVELOPMENT; ESTROGEN-RECEPTOR; EXPRESSION; INTERLEUKIN-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Hynes, NE Friedrich Miescher Inst, R-1066-206,Maulbeerstr 66, CH-4058 Basel, Switzerland Friedrich Miescher Inst R-1066-206,Maulbeerstr 66 Basel Switzerland CH-4058
Citazione:
N.E. Hynes et al., "The ErbB receptor tyrosine family as signal integrators", ENDOCR-R CA, 8(3), 2001, pp. 151-159

Abstract

ErbB receptor tyrosine kinases (RTKs) and their ligands have important roles in normal development and in human cancer. Among the ErbB receptors onlyErbB2 has no direct ligand; however, ErbB2 acts as a co-receptor for the other family members, promoting high affinity ligand binding and enhancementof ligand-induced biological responses. These characteristics demonstrate the central role of ErbB2 in the receptor family, which likely explains whyit is involved in the development of many human malignancies, including breast cancer. ErbB RTKs also function as signal integrators, cross-regulating different classes of membrane receptors including receptors of the cytokine family. Cross-regulation of ErbB RTKs and cytokines receptors representsanother mechanism for controlling and enhancing tumor cell proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:43:39