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Titolo:
A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila
Autore:
Yagi, R; Ishimaru, S; Yano, H; Gaul, U; Hanafusa, H; Sabe, H;
Indirizzi:
Osaka Biosci Inst, Dept Mol Biol, Suita, Osaka 5650874, Japan Osaka BiosciInst Suita Osaka Japan 5650874 , Suita, Osaka 5650874, Japan Osaka Biosci Inst, Dept Mol Oncol, Suita, Osaka 5650874, Japan Osaka Biosci Inst Suita Osaka Japan 5650874 , Suita, Osaka 5650874, Japan Kyoto Univ, Sch Biostudies, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 iostudies, Sakyo Ku, Kyoto 6068502, Japan Rockefeller Univ, Lab Dev Neurogenet, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 Neurogenet, New York, NY 10021 USA
Titolo Testata:
EMBO REPORTS
fascicolo: 9, volume: 2, anno: 2001,
pagine: 814 - 820
SICI:
1469-221X(200109)2:9<814:ANMLPI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION; TYROSINE PHOSPHORYLATION; CELL-MIGRATION; DOMAIN PROTEINS; BINDING; ACTIN; DIFFERENTIATION; LOCALIZATION; CYTOSKELETON; MYOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Sabe, H Osaka Biosci Inst, Dept Mol Biol, Suita, Osaka 5650874, Japan Osaka Biosci Inst Suita Osaka Japan 5650874 Osaka 5650874, Japan
Citazione:
R. Yagi et al., "A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila", EMBO REP, 2(9), 2001, pp. 814-820

Abstract

Paxillin is a protein containing four LIM domains, and functions in integrin signaling. We report here that two transcripts are generated from the paxillin gene locus in Drosophila; one encodes a protein homolog of the vertebrate Paxillin (DPxn37), and the other a protein with only three LIM domains, partly encoded by its own specific exon (PDLP). At the myotendinous junctions of Drosophila embryos where integrins play important roles, both DPxn37 and PDLP are highly expressed with different patterns; DPxn37 is predominantly concentrated at the center of the junctions, whereas PDLP is highly enriched at neighboring sides of the junction centers, primarily expressed in the mesodermal myotubes. Northern blot analysis revealed that DPxn37 is ubiquitously expressed throughout the life cycle, whereas PDLP expression exhibits a biphasic pattern during development, largely concomitant with muscle generation and remodeling. Our results collectively reveal that a unique system exists in Drosophila for the generation of a novel type of LIM-only protein, highly expressed in the embryonic musclature, largely utilizing the Paxillin LIM domains.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:03:35