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Titolo:
Estrogen receptors: orchestrators of pleiotropic cellular responses
Autore:
Moggs, JG; Orphanides, G;
Indirizzi:
Syngenta Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Syngenta Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ England
Titolo Testata:
EMBO REPORTS
fascicolo: 9, volume: 2, anno: 2001,
pagine: 775 - 781
SICI:
1469-221X(200109)2:9<775:EROOPC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTONE ACETYLATION; ER-ALPHA; BETA; TRANSCRIPTION; COACTIVATOR; ACTIVATION; PHOSPHORYLATION; RECRUITMENT; CHROMATIN; COMPLEX;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Moggs, JG Syngenta Cent Toxicol Lab, Alderley Pk, Macclesfield SK10 4TJ, Cheshire, England Syngenta Cent Toxicol Lab Alderley Pk Macclesfield Cheshire England SK10 4TJ
Citazione:
J.G. Moggs e G. Orphanides, "Estrogen receptors: orchestrators of pleiotropic cellular responses", EMBO REP, 2(9), 2001, pp. 775-781

Abstract

Estrogen receptors (ERs) orchestrate both transcriptional and non-genomic functions in response to estrogens, xenoestrogens and signals emanating from growth factor signalling pathways. The pleiotropic and tissue-specific effects of estrogens are likely to be mediated by the differential expressionof distinct estrogen receptor subtypes (ER alpha and ER beta) and their coregulators. The recent analysis of transcription complexes associated with estrogen-responsive promoters has revealed unexpected levels of complexity in the dynamics of ER-mediated transcription. Furthermore, a small fractionof ERs also appears to directly interact with components of the cytosolic signalling machinery. Analysis of the interrelationship between these distinct modes of ER action is likely to reveal novel aspects of estrogen signalling that will impact on nuclear receptor biology and human health.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:38:55