Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association of lipoprotein(a) levels and apolipoprotein(a) phenotypes withcoronary artery disease in Type 2 diabetic patients and in non-diabetic subjects
Autore:
Gazzaruso, C; Garzaniti, A; Falcone, C; Geroldi, D; Finardi, G; Fratino, P;
Indirizzi:
IRCCS Maugeri Fdn Hosp, Sect Internal Med, Ctr Diabet,Chair Internal Med, Dept Internal Med & Med Therapeut, I-27100 Pavia, Italy IRCCS Maugeri Fdn Hosp Pavia Italy I-27100 erapeut, I-27100 Pavia, Italy IRCCS Policlin San Matteo, Cardiol Sect, Pavia, Italy IRCCS Policlin San Matteo Pavia Italy atteo, Cardiol Sect, Pavia, Italy Univ Pavia, Dept Internal Med & Med Therapeut, Sect Internal Med Vasc & Metab Dis, IRCCS Policlin San Matteo, I-27100 Pavia, Italy Univ Pavia PaviaItaly I-27100 Policlin San Matteo, I-27100 Pavia, Italy
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 7, volume: 18, anno: 2001,
pagine: 589 - 594
SICI:
0742-3071(200107)18:7<589:AOLLAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-DISEASE; SERUM LIPOPROTEIN(A); RISK FACTOR; CARDIOVASCULAR MORTALITY; NIDDM PATIENTS; MELLITUS; POLYMORPHISM; SEVERITY; MEN; COMPLICATIONS;
Keywords:
lipoproteins; apolipoproteins; genetics; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Gazzaruso, C IRCCS Maugeri Fdn Hosp, Sect Internal Med, Ctr Diabet,Chair Internal Med, Dept Internal Med & Med Therapeut, Via Ferrata 8, I-27100 Pavia, Italy IRCCS Maugeri Fdn Hosp Via Ferrata 8 Pavia Italy I-27100 aly
Citazione:
C. Gazzaruso et al., "Association of lipoprotein(a) levels and apolipoprotein(a) phenotypes withcoronary artery disease in Type 2 diabetic patients and in non-diabetic subjects", DIABET MED, 18(7), 2001, pp. 589-594

Abstract

Aims We investigated whether in Type 2 diabetic patients lipoprotein(a) (Lp(a)) levels and apolipoprotein(a) (apo(a)) polymorphism are associated with angiographically documented coronary artery disease (CAD). We also examined whether there are differences in the distributions of Lp(a) levels and apo(a) phenotypes between CAD patients with and without diabetes. Methods A hundred and seven diabetic patients with CAD, 274 diabetic patients without CAD, 201 non-diabetic patients with CAD, and 358 controls were enrolled. Results Diabetic patients with CAD showed Lp(a) levels (21.2 +/- 17.7 vs. 15.1 +/- 17.8 mg/dl; P=0.0018) and a percentage of subjects with at least one apo(a) isoform of low molecular weight (MW) (67.2% vs. 27.7%; P=0.0000) significantly greater than diabetic patients without CAD. Multivariate analysis showed that in diabetic patients Lp(a) levels and apo(a) phenotypes were significantly associated with CAD; odds ratios (ORs) of high Lp(a) levels for CAD were 2.17 (1.28-3.66), while ORs of the presence of at least one apo(a) isoform of low MW were 5.35 (3.30-8.60). Lp(a) levels (30.2 +/- 23.7vs. 21.2 +/- 17.7 mg/dl; P=0.0005) and the percentage of subjects with at least one apo(a) isoform of low MW (87.0% vs. 67.2%; P=0.0001) were significantly higher in CAD patients without than in those with diabetes. Conclusions Our data suggest that Lp(a) levels and apo(a) phenotypes are independently associated with CAD in Type 2 diabetic patients; thus both these parameters may be helpful in selecting diabetic subjects at high geneticcardiovascular risk. However, Lp(a) levels and apo(a) polymorphism seem tobe cardiovascular risk factors less important in diabetic than in non-diabetic subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 04:15:23