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Titolo:
Low prevalence of cardiac autonomic neuropathy in Type 1 diabetic patientswithout nephropathy
Autore:
Meinhold, JA; Maslowska-Wessel, E; Bender, R; Sawicki, PT;
Indirizzi:
Univ Dusseldorf, Dept Metab Dis & Nutr, WHO, Collaborating Ctr Diabet, D-40001 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 8, volume: 18, anno: 2001,
pagine: 607 - 613
SICI:
0742-3071(200108)18:8<607:LPOCAN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; QT INTERVAL; DISEASE DURATION; IDDM PATIENTS; MELLITUS; MORTALITY; DYSFUNCTION; PROLONGATION; ASSOCIATION; REFLEXES;
Keywords:
cardiac autonomic neuropathy; Type 1 diabetes; diabetic nephropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Meinhold, JA Univ Dusseldorf, Dept Metab Dis & Nutr, WHO, Collaborating Ctr Diabet, POB10 10 07, D-40001 Dusseldorf, Germany Univ Dusseldorf POB 10 10 07 Dusseldorf Germany D-40001 many
Citazione:
J.A. Meinhold et al., "Low prevalence of cardiac autonomic neuropathy in Type 1 diabetic patientswithout nephropathy", DIABET MED, 18(8), 2001, pp. 607-613

Abstract

Aim To assess the prevalence of cardiac autonomic neuropathy (CAN) in Type1 diabetic patients with and without nephropathy. Methods Sixty-six consecutive patients without nephropathy (n = 24), with incipient (n = 26) or overt nephropathy (n = 16) and a diabetes duration between 21 and 31 years were examined. Heart rate variability (HRV) as measure for CAN was investigated with short-term spectral analysis in the low-frequency (LF) band (0.06-0.15 Hz), reflecting sympathetic and vagal activity,and high-frequency (HF) band (0.15-0.50 Hz), reflecting vagal activity. HRV was expressed as spectral power (ms(2), log-transformed). Normal, age-corresponding reference values were established in 184 controls. QTc intervalsand dispersion were measured. Results After adjustment for age, there was no significant difference between healthy controls and patients without nephropathy. After further adjustment for diabetes duration, HbA(1c), hypertension and treatment with P-blockers, HRV in both frequency bands decreased with evidence of nephropathy. LF band (supine): patients without nephropathy 5.56 (4.89-6.21) (least squares means and 95% confidence interval (CI)), incipient nephropathy 5.72 (5.15-6.29) and overt nephropathy 4.11 (3.27-4.96). HF band (supine): without nephropathy 5.93 (5.26-6.60), incipient nephropathy 5.99 (5.41-6.57) and overt nephropathy 4.84 (4.00-5.68). Significant differences were found for patients without and with incipient nephropathy compared with those with overtnephropathy in the LF band and between patients with incipient nephropathycompared with those with overt nephropathy in the HF band. QTc intervals and QTc dispersion increased significantly with increasing nephropathy. Conclusions Long-term Type 1 diabetes without nephropathy was not associated with impaired cardiac autonomic function in our study. However, in thosewith nephropathy, a loss of both vagal and sympathetic activity was present, and the severity of CAN correlated positively with more advanced nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 10:14:51