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Titolo:
The relation of markers of inflammation to the development of glucose disorders in the elderly - The cardiovascular health study
Autore:
Barzilay, JI; Abraham, L; Heckbert, SR; Cushman, M; Kuller, LH; Resnick, HE; Tracy, RP;
Indirizzi:
Kaiser Permanente Georgia, Div Endocrinol, Tucker, GA 30084 USA Kaiser Permanente Georgia Tucker GA USA 30084 rinol, Tucker, GA 30084 USA Emory Univ, Sch Med, Div Endocrinol, Atlanta, GA USA Emory Univ Atlanta GA USA Univ, Sch Med, Div Endocrinol, Atlanta, GA USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Vermont, Dept Med, Coll Med, Colchester, VT USA Univ Vermont Colchester VT USA t, Dept Med, Coll Med, Colchester, VT USA Univ Vermont, Dept Pathol, Coll Med, Colchester, VT USA Univ Vermont Colchester VT USA Dept Pathol, Coll Med, Colchester, VT USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA th, Dept Epidemiol, Pittsburgh, PA USA Medstar Res Inst, Washington, DC USA Medstar Res Inst Washington DC USAMedstar Res Inst, Washington, DC USA
Titolo Testata:
DIABETES
fascicolo: 10, volume: 50, anno: 2001,
pagine: 2384 - 2389
SICI:
0012-1797(200110)50:10<2384:TROMOI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; GLUTAMIC-ACID DECARBOXYLASE; INNATE IMMUNE-SYSTEM; ACUTE-PHASE RESPONSE; INSULIN-RESISTANCE; DIABETES-MELLITUS; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; ADIPOSE-TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Barzilay, JI Kaiser Permanente Georgia, Div Endocrinol, 200 Crescent Ctr Pkwy, Tucker, GA 30084 USA Kaiser Permanente Georgia 200 Crescent Ctr Pkwy Tucker GA USA 30084
Citazione:
J.I. Barzilay et al., "The relation of markers of inflammation to the development of glucose disorders in the elderly - The cardiovascular health study", DIABETES, 50(10), 2001, pp. 2384-2389

Abstract

Several studies suggest that inflammation plays a role in the pathogenesisof some glucose disorders in adults. We tested this hypothesis in a longitudinal cohort study of older individuals who had normal fasting glucose (FG) values at baseline. We compared the baseline levels of six inflammatory markers in participants who had developed glucose disorders at follow-up with those of participants whose FG remained normal at follow-up. Participantswere members of the Cardiovascular Health Study, a prospective study of risk factors for cardiovascular disease in adults greater than or equal to 65years. All 5,888 participants had baseline testing, including FG and markers of inflammation: white blood cell and platelet counts and albumin, fibrinogen, C-reactive protein (CRP), and factor VIIIc levels. At 3-4 years of follow-up, 4,481 (84.5%) of those who were alive had FG levels retested. Participants who developed diabetes (n = 45) had higher median levels of CRP at baseline than those who remained normoglycemic. On multivariate analysis,those with elevated CRP levels (75th percentile [2.86 mg/l] vs. 25th percentile [0.82 mg/l]) were 2.03 times (95% confidence intervals, 1.44-2.86) more likely to have diabetes on follow-up. Adjustment for confounders and other inflammatory markers did not appreciably change this finding. There was no relationship between the development of diabetes and other markers of inflammation. Inflammation, as measured by CRP levels, is associated with thedevelopment of diabetes in the elderly. Understanding the role of inflammation in the pathogenesis of glucose disorders in this age-group may lead tobetter classification and treatment of glucose disorders among them.

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Documento generato il 29/11/20 alle ore 00:58:25