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Titolo:
Effect of raloxifene on serum triglycerides in postmenopausal women: Influence of predisposing factors for hypertriglyceridemia
Autore:
Mosca, L; Harper, K; Sarkar, S; OGorman, J; Anderson, PW; Cox, DA; Barrett-Connor, E;
Indirizzi:
Cornell Univ, New York, NY 10032 USA Cornell Univ New York NY USA 10032Cornell Univ, New York, NY 10032 USA Columbia Univ, New York, NY 10032 USA Columbia Univ New York NY USA 10032Columbia Univ, New York, NY 10032 USA Columbia Univ, New York Presbyterian Hosp, New York, NY 10032 USA ColumbiaUniv New York NY USA 10032 byterian Hosp, New York, NY 10032 USA Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & CoIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA Univ Calif San Diego, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Diego, La Jolla, CA 92093 USA
Titolo Testata:
CLINICAL THERAPEUTICS
fascicolo: 9, volume: 23, anno: 2001,
pagine: 1552 - 1565
SICI:
0149-2918(200109)23:9<1552:EOROST>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; HORMONE REPLACEMENT THERAPY; RANDOMIZED TRIAL; BREAST-CANCER; PANCREATITIS; RISK; PREVENTION; SECONDARY; REDUCTION; TAMOXIFEN;
Keywords:
raloxifene; selective estrogen-receptor modulator; hypertriglyceridemia; triglycerides; lipids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mosca, L Columbia Univ, New York Presbyterian Hosp, ICCR PH 10-203B,622 W 168th St,New York, NY 10032 USA Columbia Univ ICCR PH 10-203B,622 W 168th St New York NY USA 10032
Citazione:
L. Mosca et al., "Effect of raloxifene on serum triglycerides in postmenopausal women: Influence of predisposing factors for hypertriglyceridemia", CLIN THER, 23(9), 2001, pp. 1552-1565

Abstract

Background. Estrogen increases serum triglyceride (TG) levels and induces hypertriglyceridemia in susceptible women. The effect of raloxifene (RLX), a selective estrogen-receptor modulator, on serum TG has not been studied in detail. Objective: The purpose of this study was to examine the effect of RLX on serum TG levels in postmenopausal women with and without osteoporosis, including those with predisposing factors for hypertriglyceridemia. Methods: Fasting serum TG levels were assessed over 36 months in 2738 osteoporotic postmenopausal women (mean age, 67 years) assigned to placebo or RLX (60 or 120 mg/d) in an osteoporosis treatment trial and over 24 months in 1318 postmenopausal women without osteoporosis (mean age, 54 years) assigned to placebo or RLX (60 or 150 mg/d) in 3 osteoporosis prevention trials. Results: In the osteoporosis treatment trial, the median serum TG concentration decreased in all groups, but significantly more in the placebo group (placebo, -3.4%; RLX 60 mg/d, -1.4%; RLX 120 mg/d, -1.3%; P=0.002). In the osteoporosis prevention trials, the percentage change in median serum TG concentration was not significantly different among treatments (P=0.22). Among women with varying degrees of hypertriglyceridemia at baseline (>2.82, >3.39, and >4.51 mmol/L), the median serum TG level at the end of the study decreased from baseline in all groups, with no significant differences amongtreatments (P greater than or equal to0.13). The effect of RLX on serum TGlevel was not influenced by age, smoking status, use of alcohol, or presence of diabetes (P greater than or equal to0.10 for all interactions). Amongwomen in the highest tertile of body mass index (>26.4 kg/m(2)), RLX increased serum TG levels significantly compared with placebo (placebo, -3%; RLX60 mg/d, 6%; RLX 120 mg/d, 4%; P<0.05); the absolute increase from baseline with RLX in this sub Group was 0.05 mmol/L (4.4 mg/dL). Conclusions: RLX did not increase serum TG in postmenopausal women overallor among women with elevated TG levels or evidence of diabetes at baseline. TG levels increased slightly but statistically significantly in women in the upper tertile of body mass index who were treated with RLX.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:41:02