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Titolo:
Acute spinal cord injury, part I: Pathophysiologic mechanisms
Autore:
Dumont, RJ; Okonkwo, DO; Verma, RS; Hurlbert, RJ; Boulos, PT; Ellegala, DB; Dumont, AS;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Neurol Surg, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ British Columbia, Fac Med, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada Fac Med, Vancouver, BC, Canada Univ Calgary, Div Neurosurg, Calgary, AB, Canada Univ Calgary Calgary AB Canada lgary, Div Neurosurg, Calgary, AB, Canada Univ Calgary, Spine Program, Calgary, AB, Canada Univ Calgary Calgary AB Canada lgary, Spine Program, Calgary, AB, Canada
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 254 - 264
SICI:
0362-5664(200109/10)24:5<254:ASCIPI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC BRAIN INJURY; CENTRAL-NERVOUS-SYSTEM; SCANNING ELECTRON-MICROSCOPY; ISCHEMIA-REPERFUSION INJURY; VASCULAR CORROSION CASTS; FREE-RADICAL PRODUCTION; EXCITATORY AMINO-ACIDS; FINAL COMMON PATHWAY; RAT CEREBRAL-CORTEX; NITRIC-OXIDE;
Keywords:
spinal cord injury; secondary injury; pathophysiologic mechanisms;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Dumont, AS Univ Virginia, Hlth Sci Ctr, Dept Neurol Surg, Box 212, Charlottesville, VA 22908 USA Univ Virginia Box 212 Charlottesville VA USA 22908 VA 22908 USA
Citazione:
R.J. Dumont et al., "Acute spinal cord injury, part I: Pathophysiologic mechanisms", CLIN NEUROP, 24(5), 2001, pp. 254-264

Abstract

Spinal cord injury (SCI) is a devastating and common neurologic disorder that has profound influences on modem society from physical, psychosocial, and socioeconomic perspectives. Accordingly, the present decade has been labeled the Decade of the Spine to emphasize the importance of SCI and other spinal disorders. Spinal cord injury may be divided into both primary and secondary mechanisms of injury. The primary injury, in large part, determinesa given patient's neurologic grade on admission and thereby is the strongest prognostic indicator. However. secondary mechanisms of injury can exacerbate damage and limit restorative processes, and hence, contribute to overall morbidity and mortality. A burgeoning body of evidence has facilitated our understanding of these secondary mechanisms of injury that are amenable to pharmacological interventions, unlike the primary injury itself, Secondary mechanisms of injury encompass an array of perturbances and include neurogenic shock, vascular insults such as hemorrhage and ischemia-reperfusion,excitotoxicity, calcium-mediated secondary injury and fluid-electrolyte disturbances, immunologic injury, apoptosis, disturbances in mitochondrion function, and other miscellaneous processes, Comprehension of secondary mechanisms of injury serves as a basis for the development and application of targeted pharmacological strategies to confer neuroprotection and restorationwhile mitigating ongoing neural injury. The first article in this series will comprehensively review the pathophysiology of SCI while emphasizing those mechanisms for which pharmacologic therapy has been developed, and the second article reviews the pharmacologic interventions for SCI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:33:54