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Titolo:
Salivary cytomegalovirus (CMV) shedding, glycoprotein B genotype distribution, and CMV disease in human immunodeficiency virus-seropositive patients
Autore:
Fidouh-Houhou, N; Duval, X; Bissuel, F; Bourbonneux, V; Flandre, P; Ecobichon, JL; Jordn, MC; Vilde, JL; Brun-Vezinet, F; Leport, C;
Indirizzi:
Hop Bichat Claude Bernard, Dept Infect & Trop Dis, Serv Malad Infect & Trop, F-75018 Paris 18, France Hop Bichat Claude Bernard Paris France 18 Trop, F-75018 Paris 18, France Hop Bichat Claude Bernard, Dept Virol, F-75018 Paris, France Hop Bichat Claude Bernard Paris France F-75018 ol, F-75018 Paris, France Paul Brousse Villejuif Hosp, INSERM SC10, Villejuif, France Paul Brousse Villejuif Hosp Villejuif France RM SC10, Villejuif, France Oregon Hlth Sci Univ, Div Infect Dis, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 ct Dis, Portland, OR 97201 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 8, volume: 33, anno: 2001,
pagine: 1406 - 1411
SICI:
1058-4838(20011015)33:8<1406:SC(SGB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DAY-CARE-CENTERS; MOLECULAR EPIDEMIOLOGY; RECIPIENTS; RETINITIS; INFECTION; CHILDREN; STRAINS; VIREMIA; URINE; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Duval, X Hop Bichat Claude Bernard, Dept Infect & Trop Dis, Serv Malad Infect & Trop, 46 Rue Henri Huchard, F-75018 Paris 18, France Hop Bichat Claude Bernard 46 Rue Henri Huchard Paris France 18 e
Citazione:
N. Fidouh-Houhou et al., "Salivary cytomegalovirus (CMV) shedding, glycoprotein B genotype distribution, and CMV disease in human immunodeficiency virus-seropositive patients", CLIN INF D, 33(8), 2001, pp. 1406-1411

Abstract

To assess the frequency of shedding of cytomegalovirus (CMV) in saliva, the distribution of CMV glycoprotein B (gB) genotypes, and the occurrence of CMV diseases, we screened 98 human immunodeficiency virus (HIV)- seropositive patients without CMV disease. CMV was detected by culture more frequently in saliva (45 [46%] of 98 patients) than in blood (7 [7.5%] of 93) and was associated with CD4 cell counts <100 cells/mm(3) (P = .013). CMV in the saliva of 37 patients was successfully genotyped. Three patients (8%) were infected by a gB1 strain, 26 (70%) by a gB2 strain, 2 (5.5%) by a gB3 strain, 1 (3%) by a gB4 strain, and 5 (13.5%) by mixed gB strains. Thirteen patients developed CMV disease after a mean period of 143 +/- 112 days; at inclusion, 9 (69%) had salivary CMV shedding and 2 had CMV viremia. CMV salivaryshedding (P = .043), low CD4(+) cell count (P = .041), and CMV viremia (P = .011) were associated with occurrence of CMV disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 14:41:39