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Titolo:
Downregulation of urokinase-type plasminogen activator receptor (uPAR) induces caspase-mediated cell death in human glioblastoma cells
Autore:
Yanamandra, N; Konduri, SD; Mohanam, S; Dinh, DH; Olivero, WC; Gujrati, M; Nicolson, GL; Obeyeseke, M; Rao, JS;
Indirizzi:
Univ Illinois, Coll Med, Dept Biomed & Therapeut Sci, Div Canc Biol, Peoria, IL 61605 USA Univ Illinois Peoria IL USA 61605 ci, Div Canc Biol, Peoria, IL 61605 USA Univ Illinois, Coll Med, Dept Neurosurg, Div Canc Biol, Peoria, IL 61605 USA Univ Illinois Peoria IL USA 61605 rg, Div Canc Biol, Peoria, IL 61605 USA Univ Illinois, Coll Med, Dept Neuropathol, Div Canc Biol, Peoria, IL 61605USA Univ Illinois Peoria IL USA 61605 hol, Div Canc Biol, Peoria, IL 61605USA Inst Mol Med, Huntington Beach, CA USA Inst Mol Med Huntington Beach CA USA t Mol Med, Huntington Beach, CA USA Univ Texas, MD Anderson Canc Ctr, Dept Biomath, Houston, TX 77030 USA UnivTexas Houston TX USA 77030 Ctr, Dept Biomath, Houston, TX 77030 USA
Titolo Testata:
CLINICAL & EXPERIMENTAL METASTASIS
fascicolo: 7, volume: 18, anno: 2001,
pagine: 611 - 615
SICI:
0262-0898(2001)18:7<611:DOUPAR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOPTOSIS; CED-4; INVASIVENESS; MITOCHONDRIA; EXPRESSION; INHIBITION; ENCODES; PROTEIN; GENES;
Keywords:
antisense; caspases; glioblastoma; oligonucleotides; uPAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Rao, JS Univ Illinois, Coll Med, Dept Biomed & Therapeut Sci, Div Canc Biol, 1 Illini Dr, Peoria, IL 61605 USA Univ Illinois 1 Illini Dr Peoria IL USA 61605 Peoria, IL 61605 USA
Citazione:
N. Yanamandra et al., "Downregulation of urokinase-type plasminogen activator receptor (uPAR) induces caspase-mediated cell death in human glioblastoma cells", CLIN EXP M, 18(7), 2001, pp. 611-615

Abstract

Urokinase-type plasminogen activator receptors (uPARs) play an important role in tumor invasion by localizing degradative enzymes at the invasive zone. Our previous studies with human glioblastoma cell line SNB19 expressing AS-uPAR stable tranfectant lose their invasive properties when injected in vivo. The aim of the present study is to investigate whether the inhibitionof tumor formation is due to apoptosis. Apoptosis is a highly conserved cell suicide program essential for development and tissue homeostasis of all metazoan organisms. Key to the apoptotic program is a family of cystein proteases termed caspases, which are important for execution of apoptosis by cleavage of essential cellular proteins. We found loss of mitochondrial transmembrane potential, release of cytochrome C from mitochondria and subsequent activation of Caspase-9 in SNB19 AS-uPAR cells compared to parental and vector controls. Our results indicate that suppression of uPAR results in apoptosis and suggest that Caspase-9 dependent apoptosis plays an important role in SNB19 AS-uPAR-induced apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:37:55