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Titolo:
Gelatin sheet incorporating basic fibroblast growth factor enhances healing of devascularized sternum in diabetic rats
Autore:
Iwakura, A; Tabata, Y; Tamura, N; Doi, K; Nishimura, K; Nakamura, T; Shimizu, Y; Fujita, M; Komeda, M;
Indirizzi:
Kyoto Univ, Dept Cardiovasc Surg, Sch Med, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ovasc Surg, Sch Med, Kyoto 6068507, Japan Kyoto Univ, Inst Frontier Sci, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Inst Frontier Sci, Kyoto, Japan Kyoto Univ, Coll Med Technol, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 yoto Univ, Coll Med Technol, Kyoto 606, Japan
Titolo Testata:
CIRCULATION
fascicolo: 12, volume: 104, anno: 2001, supplemento:, S
pagine: I325 - I329
SICI:
0009-7322(20010918)104:12<I325:GSIBFG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAN STERNOTOMY; WOUND-INFECTION; ARTERY; COMPLICATIONS; DEEP; RISK; BONE;
Keywords:
angiogenesis; growth substances; diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Komeda, M Kyoto Univ, Dept Cardiovasc Surg, Sch Med, 54 Kawaharacho, Kyoto6068507, Japan Kyoto Univ 54 Kawaharacho Kyoto Japan 6068507 to 6068507, Japan
Citazione:
A. Iwakura et al., "Gelatin sheet incorporating basic fibroblast growth factor enhances healing of devascularized sternum in diabetic rats", CIRCULATION, 104(12), 2001, pp. I325-I329

Abstract

Background-Poor healing of the sternum often limits the use of bilateral internal thoracic arteries (BITAs) after coronary bypass surgery in diabeticpatients. We have reported that a gelatin sheet that incorporates basic fibroblast growth factor (bFGF) accelerates sternal healing after BITA removal in normal rats. This study evaluated the effects of the above method for sternal healing in diabetic animals. Methods and Results-Diabetic Wistar rats with blood glucose levels > 400 mg/dL and body-weight loss > 20 g were established by a single intravenous injection of streptozotocin (55 mg/kg). After median sternotomy and BITA removal, 16 diabetic rats received either a gelatin sheet that incorporated bFGF (100 mug/sheet) on the posterior table of the sternum (FGF group. n=9) or no gelatin sheet (control, n=7). Peristernal blood flow, as measured by anoncontact laser Doppler 4 weeks after surgery in the FGF group, recoveredto the preoperative level (106 +/- 10% versus 82 +/-9%, P <0.01), and marked angiogenesis was also observed around the sternum in the FGF group (30.5+/-3.2 versus 15.8 +/-2.7 vessels/unit area, P <0.01). Deep sternal wound complications developed in 5 control rats but only in I rat in the FGF group (P <0.05). In the FGF group, histological examination showed improved sternal healing (excellent in 6 rats and slow/poor healing in 3). Bone mineralcontent as assessed by dual-energy x-ray absorptometry was greater in the FGF group (75.9 +/- 18.1 versus 48.9 +/- 10.7 mg, P <0.05). Bone mineral density of the sternum was similar between the 2 groups. Conclusions-A gelatin sheet that incorporates bFGF may offset sternal ischemia and accelerate sternal bone regeneration and healing, even in diabeticpatients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:53:00