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Titolo:
Complement activation in patients with congestive heart failure - Effect of high-dose intravenous immunoglobulin treatment
Autore:
Aukrust, P; Gullestad, L; Lappegard, KT; Ueland, T; Aass, H; Wikeby, L; Simonsen, S; Froland, SS; Mollnes, TE;
Indirizzi:
Univ Oslo, Rikshosp, Sect Clin Immunol & Infect Dis, Dept Med, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 & Infect Dis, Dept Med, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Internal Med Res Inst, N-0027 Oslo, Norway Univ OsloOslo Norway N-0027 Internal Med Res Inst, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo OsloNorway N-0027 shosp, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Nordland Cent Hosp, Dept Immunol & Transfus Med, Bodo, Norway Nordland Cent Hosp Bodo Norway ept Immunol & Transfus Med, Bodo, Norway Nordland Cent Hosp, Dept Med, Bodo, Norway Nordland Cent Hosp Bodo Norway rdland Cent Hosp, Dept Med, Bodo, Norway Univ Tromso, Dept Immunol & Transfus Med, Bodo, Norway Univ Tromso Bodo Norway omso, Dept Immunol & Transfus Med, Bodo, Norway Univ Tromso, Dept Med, Bodo, Norway Univ Tromso Bodo NorwayUniv Tromso, Dept Med, Bodo, Norway
Titolo Testata:
CIRCULATION
fascicolo: 13, volume: 104, anno: 2001,
pagine: 1494 - 1500
SICI:
0009-7322(20010925)104:13<1494:CAIPWC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; IN-VITRO; QUANTIFICATION; AUTOIMMUNE; EXPRESSION; RECEPTOR; DISEASE;
Keywords:
heart failure; inflammation; leukocytes; immunology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Aukrust, P Univ Oslo, Rikshosp, Sect Clin Immunol & Infect Dis, Dept Med, Sognsvannsveien 20, N-0027 Oslo, Norway Univ Oslo Sognsvannsveien 20 Oslo Norway N-0027 7 Oslo, Norway
Citazione:
P. Aukrust et al., "Complement activation in patients with congestive heart failure - Effect of high-dose intravenous immunoglobulin treatment", CIRCULATION, 104(13), 2001, pp. 1494-1500

Abstract

Background-Increasing evidence implicates innate immunity in the pathogenesis of congestive heart failure (CHF). In the present study, we examined the possible role of complement, an important part of innate immunity, in CHF. Methods and Results-Complement activation was analyzed in systemic and coronary circulation in 39 patients with CHF and 20 healthy control subjects. In a double-blind, placebo-controlled study, we have recently reported thathigh-dose intravenous immunoglobulin (IVIG) improves left ventricular ejection fraction (LVEF) in these patients. To examine if this improvement was related to IVIG-induced effects on complement, we also examined complement activation during induction (first week) and maintenance therapy (6 months)with IVIG or placebo. Our main findings were: (1) We found enhanced systemic complement activation involving classic, alternative, as well as terminal pathway in patients with CHF compared with healthy control subjects. (2) Particularly enhanced complement activation was found in coronary sinus, representing venous drainage from the heart. (3) The systemic complement activation was further enhanced during IVIG but not during placebo therapy, particularly during induction therapy. (4) Although IVIG improved LVEF in patients with CHF, the degree of IVIG-mediated complement activation was negatively correlated with this improvement of LVEF. Conclusions-This study further supports the involvement of innate immunityin the pathogenesis of CHF. Our findings suggest that complement may be added to the list of possible therapeutic targets in CHF and that future studies with specific complement inhibitors may be of interest in this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:06:35