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Titolo:
Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells
Autore:
Park, JI; Choi, HS; Jeong, JS; Han, JY; Kim, IH;
Indirizzi:
Dong A Univ, Coll Med, Dept Biochem, Seo Gu, Pusan 602103, South Korea Dong A Univ Pusan South Korea 602103 , Seo Gu, Pusan 602103, South Korea Dong A Univ, Coll Med, Dept Pathol, Pusan 602103, South Korea Dong A UnivPusan South Korea 602103 t Pathol, Pusan 602103, South Korea Dong A Univ, Coll Med, Dept Clin Pathol, Pusan 602103, South Korea Dong A Univ Pusan South Korea 602103 n Pathol, Pusan 602103, South Korea Dong A Univ, Coll Med, Inst Med Sci, Pusan 602103, South Korea Dong A Univ Pusan South Korea 602103 Med Sci, Pusan 602103, South Korea Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cellular Biol, Houston, TX 77030 USA
Titolo Testata:
CELL GROWTH & DIFFERENTIATION
fascicolo: 9, volume: 12, anno: 2001,
pagine: 481 - 486
SICI:
1044-9523(200109)12:9<481:IOPKIH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ERYTHROID-DIFFERENTIATION; HEMATOPOIETIC GROWTH-FACTORS; ACTIVATED PROTEIN-KINASES; MAP KINASE; SIGNAL-TRANSDUCTION; SODIUM-BUTYRATE; MAMMALIAN-CELLS; PATHWAY; ERYTHROPOIETIN; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Park, JI Dong A Univ, Coll Med, Dept Biochem, Seo Gu, Dongdaesin Dong 3 Ga1, Pusan602103, South Korea Dong A Univ Dongdaesin Dong 3 Ga 1 Pusan South Korea 602103 orea
Citazione:
J.I. Park et al., "Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells", CELL GROWTH, 12(9), 2001, pp. 481-486

Abstract

Hydroxyurea is a differentiation-inducing agent of human erythroleukemia K562 cells. However, the cellular mechanisms by which hydroxyurea exerts itseffects on tumor cells, leading to the inhibition of cell growth and the induction of differentiation markers, are largely unknown. This study examined the role of different mitogen-activated protein kinase signal transduction pathways in hydroxyurea-induced erythroid differentiation of K562 cells. Using a panel of anti-extracellular signal-related kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38 phosphospecific antibodies, we demonstratedthat phosphorylation of ERK and JNK is decreased after the treatment of cells with hydroxyurea, whereas phosphorylation of p38 is increased. Moreover, inhibition of ERK activity by PD98059 induced erythroid differentiation, and it acted synergistically with hydroxyurea on hemoglobin synthesis, whereas inhibition of p38 activity by SS203580 inhibited induction of hemoglobin production by hydroxyurea. These findings suggest that the activation of p38 kinase may play important roles in the signal transduction mechanisms of hydroxyurea leading to erythroid differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:32:03