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Titolo:
Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients
Autore:
Sasaki, H; Auclair, D; Kaji, M; Fukai, I; Kiriyama, M; Yamakawa, Y; Fujii, Y; Chen, LB;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 st, Dept Canc Biol, Boston, MA 02115 USA
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 172, anno: 2001,
pagine: 37 - 42
SICI:
0304-3835(20011022)172:1<37:SLOTPA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; PROGNOSTIC FACTORS; SEQUENCE-ANALYSIS; GENE-EXPRESSION; FASCICLIN-I; METASTASIS; DISEASE; PROTEIN; CLONING; THYMUS;
Keywords:
periostin; chemiluminescence; thymoma; invasive thymoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, H Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, 1 Kawasumi, Nagoya, Aichi 4678601, Japan Nagoya City Univ 1 Kawasumi Nagoya Aichi Japan 4678601 01, Japan
Citazione:
H. Sasaki et al., "Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients", CANCER LETT, 172(1), 2001, pp. 37-42

Abstract

Periostin protein shares structural and sequence homology with fasciclin 1, which is an insect adhesion molecule. Periostin has a typical signal peptide at the N-terminal end suggesting it is a secreted protein. Recently, wedeveloped a novel sandwich chemiluminescence assay to determine serum concentrations of periostin. We investigated the serum periostin level in thymoma patients. and attempted to determine the correlation between serum periostin level and clinicopathological factors of thymoma patients who had undergone surgery between January 1994 and July 1996. Serum periostin levels were not significantly different between the thymoma patients (1264.4 +/- 122.9 ng/ml) and the normal control (962.0 +/- 118.6 ng/ml) (P = 0.0877). There was no relationship between serum periostin level and age, gender or pathological subtype. However the serum periostin level of stage IV patients (1497.0 +/- 285.8 ng/ml) was significantly higher than normal control (P = 0.0460). These data suggest that serum periostin level may indicate tumor invasion and progression of thymoma. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:38:45