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Titolo:
Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats
Autore:
Albrecht, D; Bluhdorn, R; Siegmund, H; Berger, H; Calo, G;
Indirizzi:
Humboldt Univ, Fac Med, Charite, Inst Physiol, D-10117 Berlin, Germany Humboldt Univ Berlin Germany D-10117 st Physiol, D-10117 Berlin, Germany Inst Mol Pharmacol, Berlin, Germany Inst Mol Pharmacol Berlin GermanyInst Mol Pharmacol, Berlin, Germany Univ Ferrara, Pharmacol Sect, Dept Expt & Clin Med, I-44100 Ferrara, ItalyUniv Ferrara Ferrara Italy I-44100 pt & Clin Med, I-44100 Ferrara, Italy
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 134, anno: 2001,
pagine: 333 - 342
SICI:
0007-1188(200109)134:2<333:IAONFO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GENICULATE NEURONS; ROSTRAL VENTROLATERAL MEDULLA; G-PROTEIN ACTIVATION; ORPHANIN-FQ; IN-VITRO; VENTROBASAL THALAMUS; DORSAL HORN; POTASSIUM CONDUCTANCE; SYNAPTIC TRANSMISSION; AFFERENT INHIBITION;
Keywords:
thalamus; nociceptin/orphanin F/Q; [Phe(1)Psi(CH2-NH)Gly(2)]nociceptin(1-13)NH2; Ac-RYYRIK-NH2; [Nphe(1)]-NC(1-13)NH2; bicuculline; iontophoresis; urethane;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Albrecht, D Humboldt Univ, Fac Med, Charite, Inst Physiol, Tucholskystr 2,D-10117 Berlin, Germany Humboldt Univ Tucholskystr 2 Berlin Germany D-10117 , Germany
Citazione:
D. Albrecht et al., "Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats", BR J PHARM, 134(2), 2001, pp. 333-342

Abstract

1 In this study we administered nociceptin/orphanin FQ (NC) ionotophoretically onto neurons located in functionally distinct thalamic structures of urethane-anesthetized rats. Extracellular single unit recordings were made in the media and lateral ventroposterior nucleus, posterior thalamic nucleus, zona incerta, lateral posterior nucleus, laterodorsal nucleus, ventrolateral nucleus and reticular nucleus.2 NC decreased the firing rate in 60% of thalamic neurons. This decrease in firing rate was accompanied by a significant reduction in the number of high threshold bursts.3 In about 20% of the neurons NC increased the firing rate. In most cells NC-induced increases in discharge rate could be blocked by the GABAA receptor antagonists bicuculline and SR 95531.4 The NC receptor ligands [Phe(1) psi (CH2-NH)Gly(2)] nociceptin(1-13)NH2,Ac-RYYRIK-NH2 and [Nphe(1)]NC(1-13)NH2 were also evaluated. All these peptides inhibited NC-induced changes in firing rate. In addition, in some neurons where NC inhibited firing, [Nphe(1)]NC(1-13)NH2 and Ac-RYYRIK-NH2 elicited per se an increase in firing rate, suggesting the existence of tonic innervation of thalamic neurons by NC-containing fibres.5 In NC-inhibited neurons nocistatin induced a significant increase in firing rate.6 The present study demonstrated that NC regulates various thalamic nucleirelated not only to somatosensory, but also to the visual and motor functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:47:09