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Titolo:
Premorbid body weight and its relations to primary tumour diameter in breast cancer patients; its dependence on estrogen and progesteron receptor status
Autore:
Maehle, BO; Tretli, S; Skjaerven, R; Thorsen, T;
Indirizzi:
Haukeland Hosp, Dept Pathol, Gade Inst, N-5021 Bergen, Norway Haukeland Hosp Bergen Norway N-5021 ol, Gade Inst, N-5021 Bergen, Norway Canc Registry Norway, Inst Epidemiol Canc Res, Oslo, Norway Canc Registry Norway Oslo Norway Inst Epidemiol Canc Res, Oslo, Norway Univ Bergen, Haukeland Hosp, Med Informat & Stat Sect, N-5021 Bergen, Norway Univ Bergen Bergen Norway N-5021 rmat & Stat Sect, N-5021 Bergen, Norway Univ Bergen, Haukeland Hosp, Hormone Lab, N-5021 Bergen, Norway Univ Bergen Bergen Norway N-5021 osp, Hormone Lab, N-5021 Bergen, Norway
Titolo Testata:
BREAST CANCER RESEARCH AND TREATMENT
fascicolo: 2, volume: 68, anno: 2001,
pagine: 159 - 169
SICI:
0167-6806(200107)68:2<159:PBWAIR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; NECROSIS-FACTOR-ALPHA; MASS-INDEX; ADIPOSE-TISSUE; CIGARETTE-SMOKING; OBESE GENE; SURVIVAL; PROGNOSIS; HEIGHT; RISK;
Keywords:
body weight; breast cancer; estrogen receptor status; progesteron receptor status; Quetelet's index; tumour diameter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Maehle, BO Haukeland Hosp, Dept Pathol, Gade Inst, N-5021 Bergen, Norway Haukeland Hosp Bergen Norway N-5021 st, N-5021 Bergen, Norway
Citazione:
B.O. Maehle et al., "Premorbid body weight and its relations to primary tumour diameter in breast cancer patients; its dependence on estrogen and progesteron receptor status", BREAST CANC, 68(2), 2001, pp. 159-169

Abstract

Hormonal mechanisms have been offered as an explanation for the higher frequency of large tumours, lymph node metastases and poorer prognosis in obese breast cancer patients than in lean ones. If hormonal mechanisms are important for these relations, they should probably act more strongly in patients with hormonal receptor positive tumours than in those with negative ones. We have examined if the relations between premorbid body weight or Quetelet's index (weight/height(2)) and tumour diameter are modified by estrogen receptor alpha (ER) and progesteron receptor (PgR) status. The analyses were based on 1,241 women with unilateral disease treated with modified radical mastectomy living in the geografic area of Haukeland Hospital. Their bodyweight and height have been measured as a mean 12.5 years before presentation of the disease. Body weight and Quetelet's index have been adjusted forage. The relations were studied using linear regression analyses adjustingthe effect of body weight with height and mean nuclear area of the tumour cells and adjusting the effect of Quetelet's index for mean nuclear area. The main findings showed that patients with high body weight or Quetelet's index presented more often with PgR positive tumours than lean ones. Quetelet's index was also positively related to ER. These relations were present in patients older than 50 years of age (older). Patients with large tumours (>2.0 cm) had significantly higher body weight and Quetelet's index than those with small ones. These differences were significantly present in older patients and in patients with PgR negative and ER negative - PgR negative tumours. Linear regression analyses confirmed that tumour diameter increaseswith body weight and Quetelet's index. These relations were present in both lymph node groups and in older patients. Stratification according to hormonal receptor status showed these relations to be significant in patients with ER negative, with PgR negative and those with ER negative - PgR negative tumours only. Taking age and hormonal receptor status into consideration simultaneously, both body weight and Quetelet's index were significantly related to tumour diameter in older patients with hormone receptor negative tumours. In conclusion body size was positively related to hormone receptor status and to diameter of the primary tumour. The relation to tumour diameter was present in older patients with hormone receptor negative tumours. Although hormonal mechanisms able to act on the tumour can not be excluded, mechanisms acting independent of hormonal receptors must be considered. Different mechanisms related to body fat cytokines are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:53:07