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Titolo:
Biomarker prediction of clinical outcome in operable breast cancer patients treated with tamoxifen
Autore:
Scarpi, E; De Paola, F; Sarti, M; Bajorko, P; Granato, AM; Volpi, A; Nanni, O; Maltoni, R; Amadori, D;
Indirizzi:
Pierantoni Hosp, Dept Oncol, I-47100 Forli, Italy Pierantoni Hosp Forli Italy I-47100 sp, Dept Oncol, I-47100 Forli, Italy Ist Oncol Romagnolo, I-47100 Forli, Italy Ist Oncol Romagnolo Forli Italy I-47100 Romagnolo, I-47100 Forli, Italy
Titolo Testata:
BREAST CANCER RESEARCH AND TREATMENT
fascicolo: 2, volume: 68, anno: 2001,
pagine: 101 - 110
SICI:
0167-6806(200107)68:2<101:BPOCOI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-PROLIFERATIVE ACTIVITY; PROGESTERONE-RECEPTOR STATUS; PROGNOSTIC-SIGNIFICANCE; CELL-KINETICS; PRIMARY CHEMOTHERAPY; BIOLOGIC MARKERS; FREE SURVIVAL; CARCINOMA; ESTROGEN; THERAPY;
Keywords:
biomarkers; N+ ER+ breast cancer; predictivity; tamoxifen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Scarpi, E Pierantoni Hosp, Dept Med Oncol, Via Forlanini 34, I-47100 Forli, Italy Pierantoni Hosp Via Forlanini 34 Forli Italy I-47100 rli, Italy
Citazione:
E. Scarpi et al., "Biomarker prediction of clinical outcome in operable breast cancer patients treated with tamoxifen", BREAST CANC, 68(2), 2001, pp. 101-110

Abstract

The predictivity of tumour size, oestrogen (ER) and progesterone (PgR) receptors, H-3-thymidine labelling index (TLI), c-erbB-2 and p27(kip1) expression on clinical outcome was analysed on a consecutive series of 118 postmenopausal patients with ER-positive, node-positive tumours. All patients weretreated with surgery +/- radiotherapy and adjuvant tamoxifen (30 mg/day) for at least 2 years. TLI, ER, c-erbB-2 and p27(kip1) were generally unrelated to each other. PgR was directly related to ER and inversely to c-erbB-2. Tumour size was inversely related to both c-erbB-2 and p27(kip1) expression. At a median follow-up of 75 months, 5-year relapse-free survival was significantly lower for patients with very rapidly proliferating (HR = 2.61, 95% CI = 1.34-5.08), PgR negative (HR = 2.76, 95% CI = 1.43-5.33) or relatively low ER content (HR = 2.20, 95% CI = 1.14-4.25) tumours than for patients with tumours expressing the opposite biological profiles. Overall survival was also significantly different as a function of TLI (HR = 3.47, 95% CI = 1.52-7.93) and PgR (HR = 2.27, 95% CI = 1.00-5.15). TLI and PgR maintained an independent relevance in multivariate analysis and together were capable of identifying subgroups of patients at significantly different risk of relapse and death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 20:47:49