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Titolo:
Hypoxia and oxidative stress in breast cancer - Tumour hypoxia - therapeutic considerations
Autore:
Williams, KJ; Cowen, RL; Stratford, IJ;
Indirizzi:
Univ Manchester, Dept Pharm & Pharmaceut Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England
Titolo Testata:
BREAST CANCER RESEARCH
fascicolo: 5, volume: 3, anno: 2001,
pagine: 328 - 331
SICI:
1465-542X(2001)3:5<328:HAOSIB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-THERAPY; OXYGEN DISTRIBUTION; BIOREDUCTIVE DRUG; DELIVERY SYSTEM; DT-DIAPHORASE; CELLS; TIRAPAZAMINE; REDUCTASE; COMBINATION; CARCINOMA;
Keywords:
bioreductive drugs; hypoxia; hypoxia responsive element; reductase enzymes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Stratford, IJ Univ Manchester, Dept Pharm & Pharmaceut Sci, Coupland III Bldg,Oxford Rd,Manchester M13 9PT, Lancs, England Univ Manchester Coupland III Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
K.J. Williams et al., "Hypoxia and oxidative stress in breast cancer - Tumour hypoxia - therapeutic considerations", BREAST CA R, 3(5), 2001, pp. 328-331

Abstract

Conclusive research has shown that regions of acute/chronic hypoxia, whichexist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior topatient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 09:31:09