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Titolo:
The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression
Autore:
Berx, G; Van Roy, F;
Indirizzi:
Flanders Interuniv Inst Biotechnol, Dept Mol Biol, Mol Cell Biol Unit, B-9000 Ghent, Belgium Flanders Interuniv Inst Biotechnol Ghent Belgium B-9000 0 Ghent, Belgium
Titolo Testata:
BREAST CANCER RESEARCH
fascicolo: 5, volume: 3, anno: 2001,
pagine: 289 - 293
SICI:
1465-542X(2001)3:5<289:TECAIG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA IN-SITU; TRANSCRIPTION FACTOR SNAIL; INVASION-SUPPRESSOR GENE; MAMMARY EPITHELIAL-CELLS; FAMILIAL GASTRIC-CANCER; LOBULAR CARCINOMA; P-CADHERIN; ALPHA-CATENIN; BETA-CATENIN; TUMOR-CELLS;
Keywords:
E-cadherin; methylation; mutation; transcriptional repression; tumor suppression;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Van Roy, F Flanders Interuniv Inst Biotechnol, Dept Mol Biol, Mol Cell Biol Unit, Ledeganckstr 35, B-9000 Ghent, Belgium Flanders Interuniv Inst Biotechnol Ledeganckstr 35 Ghent Belgium B-9000
Citazione:
G. Berx e F. Van Roy, "The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression", BREAST CA R, 3(5), 2001, pp. 289-293

Abstract

E-cadherin is a cell-cell adhesion protein fulfilling a prominent role in epithelial differentiation. Data from model systems suggest that E-cadherinis a potent invasion/tumor suppressor of breast cancer. Consistent with this role in breast cancer progression, partial or complete loss of E-cadherin expression has been found to correlate with poor prognosis in breast cancer patients. The E-cadherin gene (CDH1) is located on human chromosome 16q22.1, a region frequently affected with loss of heterozygosity in sporadic breast cancer. Invasive lobular breast carcinomas, which are typically completely E-cadherin-negative, often show inactivating mutations in combinationwith loss of heterozygosity of the wild-type CDH1 allele. Mutations were found at early noninvasive stages, thus associating E-cadherin mutations with loss of cell growth control and defining CDH1 as the tumor suppressor forthe lobular breast cancer subtype. Ductal breast cancers in general show heterogeneous loss of E-cadherin expression, associated with epigenetic transcriptional downregulation. It is proposed that the microenvironment at theinvasive front is transiently downregulating E-cadherin transcription. This can be associated with induction of nonepithelial cadherins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:05:35