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Titolo:
Application of cDNA microarrays to examine gene expression differences in schizophrenia
Autore:
Vawter, MP; Barrett, T; Cheadle, C; Sokolov, BP; Wood, WH; Donovan, DM; Webster, M; Freed, WJ; Becker, KG;
Indirizzi:
NIDA, Sect Plast & Dev, Cellular Neurobiol Res Branch, Baltimore, MD USA NIDA Baltimore MD USA , Cellular Neurobiol Res Branch, Baltimore, MD USA NIA, Gerontol Res Ctr, Transgen & Knockout Facil Sect, Baltimore, MD 21224USA NIA Baltimore MD USA 21224 & Knockout Facil Sect, Baltimore, MD 21224USA NIDA, Mol Neurobiol Branch, Baltimore, MD USA NIDA Baltimore MD USANIDA, Mol Neurobiol Branch, Baltimore, MD USA NIA, DNA Array Unit, Res Resources Branch, Baltimore, MD 21224 USA NIA Baltimore MD USA 21224 Res Resources Branch, Baltimore, MD 21224 USA Uniformed Serv Univ Hlth Sci, Dept Psychiat, Stanley Lab Brain Res, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci Bethesda MD USA 20814 Bethesda, MD 20814 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 5, volume: 55, anno: 2001,
pagine: 641 - 650
SICI:
0361-9230(20010715)55:5<641:AOCMTE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; 14-3-3 PROTEIN; PREFRONTAL CORTEX; BRAIN; CALMODULIN; ASSIGNMENT; PREMORTEM; ACTIVATOR; SUBUNITS; TYROSINE;
Keywords:
schizophrenia; gene expression; prefrontal cortex; cerebellum; microarray;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Vawter, MP Univ Calif Irvine, Coll Med, Dept Psychiat & Human Behav, Med Sci D433, Irvine, CA 92697 USA Univ Calif Irvine Med Sci D433 Irvine CA USA 92697 CA 92697 USA
Citazione:
M.P. Vawter et al., "Application of cDNA microarrays to examine gene expression differences in schizophrenia", BRAIN RES B, 55(5), 2001, pp. 641-650

Abstract

Using cDNA microarrays we have investigated gene expression patterns in brain regions of patients with schizophrenia. A cDNA neuroarray, comprised ofgenes related to brain function, was used to screen pools of samples from the cerebellum and prefrontal cortex from a matched set of subjects, and middle temporal gyrus, from a separate subject cohort. Samples of cerebellum and prefrontal cortex from neuroleptic naive patients were also included. Genes that passed a 3% reproducibility criterion for differential expressionin independent experiments included 21 genes for drug-treated patients and5 genes for drug-naive patients. Of these 26 genes, 10 genes were increased and 16 were decreased. Many of the differentially expressed genes were related to synaptic signaling and proteolytic functions. A smaller number of these genes were also differentially expressed in the middle temporal gyrus. The five genes that were differentially expressed in two brain regions from separate cohorts are: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; sialyltransferase; proteasome subunit, alpha type 1; ubiquitin carboxyl-terminal esterase LI; and solute carrier family 10, member 1. Identification of patterns of changes in gene expression may lead to a better understanding of the pathophysiology of schizophrenia disorders. (C) 2001 Elsevier Science Inc.

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Documento generato il 27/01/20 alle ore 07:21:17