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Titolo:
Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium
Autore:
Stewart, RJ; Chen, B; Dowlatshahi, D; MacQueen, GM; Young, LT;
Indirizzi:
McMaster Univ, Dept Psychiat & Behav Neurosci, Mood Disorders Program, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 am, Hamilton, ON L8N 3Z5, Canada
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 5, volume: 55, anno: 2001,
pagine: 625 - 629
SICI:
0361-9230(20010715)55:5<625:AITCSP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; ADENYLYL-CYCLASE ACTIVITY; POSTMORTEM BRAIN; ANTIDEPRESSANT TREATMENT; CEREBROSPINAL-FLUID; DEPRESSED SUICIDES; SUBUNIT LEVELS; PROTEIN-LEVELS; MESSENGER-RNA; CORTEX;
Keywords:
major depressive disorder; bipolar disorder; cAMP signaling; CREB; BDNF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Young, LT McMaster Univ, Dept Psychiat & Behav Neurosci, Mood Disorders Program, Room 4N81,HSC,1200 Main St W, Hamilton, ON L8N 3Z5, Canada McMaster Univ Room 4N81,HSC,1200 Main St W Hamilton ON Canada L8N 3Z5
Citazione:
R.J. Stewart et al., "Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium", BRAIN RES B, 55(5), 2001, pp. 625-629

Abstract

There is an established relationship between the monoaminergic neurotransmitter system and mood disorders. In an attempt to define further the pathophysiology of mood disorders, research is focussing on intracellular second messenger systems, including cyclic adenosine 3 ' ,5 ' -monophosphate (cAMP) and the polyphosphoinositol generated second messengers. The availabilityof tissue from the Stanley Foundation Neuropathology Consortium has offered us the opportunity to make a number of observations with respect to thesesecond messenger systems in tissue from patients with major depressive disorder and bipolar affective disorder. There is evidence that antidepressants stimulate components of the cAMP pathway in patients with depression while mood stabilizers blunt the same pathway in patients with bipolar disorder. Furthermore, downstream targets of this pathway appear to be altered in patients with mood disorders. The relations between changes in second messenger systems, gene transcription, and clinical effects of current therapeutic regimens has implications for development of novel treatments of mood disorders. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:01:16