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Titolo:
Electron microscopy of oligodendroglia in severe mental illness
Autore:
Uranova, N; Orlovskaya, D; Vikhreva, O; Zimina, I; Kolomeets, N; Vostrikov, V; Rachmanova, V;
Indirizzi:
Mental Hlth Res Ctr, Neuropathol Lab, Moscow 113152, Russia Mental Hlth Res Ctr Moscow Russia 113152 thol Lab, Moscow 113152, Russia
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 5, volume: 55, anno: 2001,
pagine: 597 - 610
SICI:
0361-9230(20010715)55:5<597:EMOOIS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; MAGNETIC-RESONANCE SPECTROSCOPY; PREFRONTAL CORTEX; SCHIZOPHRENIC-PATIENTS; MOOD DISORDERS; GLUCOSE-METABOLISM; MAJOR DEPRESSION; CAUDATE-NUCLEUS; BLOOD-FLOW; POSTMORTEM;
Keywords:
prefrontal cortex; striatum; schizophrenia; bipolar disorder; oligodendroglia; morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Uranova, N Mental Hlth Res Ctr, Neuropathol Lab, Zagorodnoe Shosse 2, Moscow 113152, Russia Mental Hlth Res Ctr Zagorodnoe Shosse 2 Moscow Russia 113152 a
Citazione:
N. Uranova et al., "Electron microscopy of oligodendroglia in severe mental illness", BRAIN RES B, 55(5), 2001, pp. 597-610

Abstract

Qualitative electron microscopy was performed to verify whether brain pathology in schizophrenia and bipolar disorder is associated with alterations of oligodendroglial cells and myelinated fibers. Ultrastructural signs of apoptosis and necrosis of oligodendroglial cells were found in the prefrontal area 10 and the caudate nucleus in both schizophrenia and bipolar disorder. Damage of myelin sheath lamellae, with the formation of concentric lamellar bodies, were detected in both brain structures in schizophrenia. There was also a significant decrease in the area of the nucleus and the volume density of mitochondria in oligodendrogliocytes in the caudate nucleus and in the prefrontal cortex in schizophrenia, as compared to normal controls. Volume density of heterochromatin was significantly increased (+14%) in the caudate nucleus in schizophrenia. The density of concentric lamellar bodies(as an indicator of damage of myelinated fibers) was dramatically increased (4.5-fold) in the caudate nucleus in schizophrenia, as compared to controls, and was positively correlated with volume density of heterochromatin. Multiple regression analysis and analysis of covariance demonstrated that these changes could not be explained by the effects of postmortem delay, age,neuroleptic medication, or gender. Pathology of oligodendroglia might be an essential feature of severe mental disorders. (C) 2001 Elsevier Science Inc.

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Documento generato il 10/12/19 alle ore 01:56:24