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Titolo:
Glial cell abnormalities in major psychiatric disorders: The evidence and implications
Autore:
Cotter, DR; Pariante, CM; Everall, IP;
Indirizzi:
Univ London Kings Coll, Inst Psychiat, Sect Expt Neuropathol & Psychiat, London SE5 8AF, England Univ London Kings Coll London England SE5 8AF t, London SE5 8AF, England Univ London Kings Coll, Inst Psychiat, Sect Clin Neuropharmacol, London SE5 8AF, England Univ London Kings Coll London England SE5 8AF l, London SE5 8AF, England
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 5, volume: 55, anno: 2001,
pagine: 585 - 595
SICI:
0361-9230(20010715)55:5<585:GCAIMP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; PREFRONTAL CORTEX; MOOD DISORDERS; SCHIZOPHRENIC-PATIENTS; RAT-BRAIN; GLUCOCORTICOID RECEPTOR; HIPPOCAMPAL-NEURONS; SYNAPTIC PLASTICITY; DEPRESSIVE DISORDER; QUINOLINIC ACID;
Keywords:
glia; schizophrenia; depression; bipolar disorder; glucocorticoids;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Cotter, DR Univ London Kings Coll, Inst Psychiat, Sect Expt Neuropathol & Psychiat, 1Windsor Walk,DeCrespigny Pk, London SE5 8AF, England Univ LondonKings Coll 1 Windsor Walk,DeCrespigny Pk London England SE5 8AF
Citazione:
D.R. Cotter et al., "Glial cell abnormalities in major psychiatric disorders: The evidence and implications", BRAIN RES B, 55(5), 2001, pp. 585-595

Abstract

Recent quantitative post-mortem investigations of the cerebral cortex haveconvincingly demonstrated cortical glial cell loss in subjects with major depression. Evidence is also mounting that glial cell loss may also be a feature of schizophrenia. These findings coincide with a re-evaluation of theimportance of glial cells in normal cortical function. In addition to their traditional roles in neuronal migration and inflammatory processes, glia are now accepted to have roles in providing trophic support to neurons, neuronal metabolism, and the formation of synapses and neurotransmission. Consequently, reduced cortical glial cell numbers could be responsible for someof the pathological changes in schizophrenia and depression, including reduced neuronal size, reduced levels of synaptic proteins, and abnormalities of cortical neurotransmission. Additionally, as astrocytes provide the energy requirements of neurons, deficient astrocyte function could account for aspects of the functional magnetic imaging abnormalities found in these disorders. We discuss the possible basis of glial cell loss in these disordersand suggest that elevated levels of glucocorticoids, due to illness-related stress or to hyperactivity of the hypothalamic-pituitary-adrenal may down-regulate glial activity and so predispose to, or exacerbate psychiatric illness through enhanced excitotoxicity. The potential therapeutic impact of agents which up-regulate glial activity or normalise glial cell numbers is also discussed. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 03:04:44