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Titolo:
A biosensor for detecting changes in cognitive processing based on nonlinear systems analysis
Autore:
Gholmieh, G; Soussou, W; Courellis, S; Marmarelis, V; Berger, T; Baudry, M;
Indirizzi:
Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 ed Engn, Los Angeles, CA 90089 USA Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA
Titolo Testata:
BIOSENSORS & BIOELECTRONICS
fascicolo: 7-8, volume: 16, anno: 2001,
pagine: 491 - 501
SICI:
0956-5663(200109)16:7-8<491:ABFDCI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL ORGANOTYPIC CULTURES; MICROELECTRODE ARRAY; SYNAPTIC DEVELOPMENT; STIMULATION; NEURONS; ELECTRODES; SLICE;
Keywords:
biosensor; hippocampal slice; nonlinear systems analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Baudry, M Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 os Angeles, CA 90089 USA
Citazione:
G. Gholmieh et al., "A biosensor for detecting changes in cognitive processing based on nonlinear systems analysis", BIOSENS BIO, 16(7-8), 2001, pp. 491-501

Abstract

A new type of biosensor, based on hippocampal slices cultured on multielectrode arrays, and using nonlinear systems analysis for the detection and classification of agents interfering with cognitive function is described. A new method for calculating first and second order kernel was applied for impulse input -spike output datasets and results are presented to show the reliability of the estimations of this parameter. We further decomposed second order kernels as a sum of nine exponentially decaying Laguerre base functions. The data indicate that the method also reliably estimates these nine parameters. Thus, the state of the system can now be described with a set of ten parameters (first order kernel plus nine coefficients of Laguerre base functions) that can be used for detection and classification purposes. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:46:20