Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Epileptiform activity in a neocortical network: a mathematical model
Autore:
Giannakopoulos, F; Bihler, U; Hauptmann, C; Luhmann, HJ;
Indirizzi:
German Natl Res Ctr Informat Technol, GMD, D-53754 St Augustin, Germany German Natl Res Ctr Informat Technol St Augustin Germany D-53754 Germany Univ Cologne, Inst Math, D-50931 Cologne, Germany Univ Cologne Cologne Germany D-50931 Inst Math, D-50931 Cologne, Germany Univ Dusseldorf, Inst Neurophysiol, D-40001 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany
Titolo Testata:
BIOLOGICAL CYBERNETICS
fascicolo: 4, volume: 85, anno: 2001,
pagine: 257 - 268
SICI:
0340-1200(200110)85:4<257:EAIANN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL SLICE; NEURAL NETWORKS; INHIBITORY NEURONS; OSCILLATIONS; BIFURCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Giannakopoulos, F German Natl Res Ctr Informat Technol, GMD, Schloss Birlinghoven, D-53754 St Augustin, Germany German Natl Res Ctr Informat Technol Schloss Birlinghoven St Augustin Germany D-53754
Citazione:
F. Giannakopoulos et al., "Epileptiform activity in a neocortical network: a mathematical model", BIOL CYBERN, 85(4), 2001, pp. 257-268

Abstract

A simple mathematical model describing the generation and propagation of epileptiform activity in a cerebral cortical network is presented. The modelconsists of a system of nonlinear delay differential equations. Physiological properties are taken into account as nonlinear transmission of signals at the synapse, temporal and spatial summation of incoming signals at the soma, active membrane characteristics, and dendritic and axonal propagation times. The influence of the connectivity and the temporal parameters on theoscillatory properties of the model is studied. The computer simulations are in agreement with experimental observations in cortical networks: whereas a weak excitatory or strong inhibitory synaptic connection strength produces a stationary status with short-lasting responses to external stimuli, increases in excitation or decreases in inhibition induce spontaneous and stimulus-evoked rhythmic discharges. Synaptic burst-like activity is observedonly for an intermediate range of excitatory and inhibitory connection strengths and external inputs. The form and duration of the bursts can also becontrolled by the temporal parameters. The results demonstrate that relatively simple mathematical equations are sufficient to model some of the network properties underlying the generation and propagation of epileptiform activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:45:23