Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT in frontal cortex induced by a 5-HT releasing drug, p-chloroamphetamine (PCA) in mice
Autore:
Yamada, J; Sugimoto, Y; Ohkura, M; Inoue, K;
Indirizzi:
Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558,Japan Kobe Pharmaceut Univ Kobe Hyogo Japan 6588558 , Kobe, Hyogo 6588558,Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 10, volume: 24, anno: 2001,
pagine: 1195 - 1197
SICI:
0918-6158(200110)24:10<1195:EOT5RA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPTOPHAN-HYDROXYLASE-ACTIVITY; SEROTONIN; BRAIN; RAT; METHAMPHETAMINE; FENFLURAMINE; MDMA; 5-HYDROXYTRYPTAMINE; CLOMETHIAZOLE; SCHIZOPHRENIA;
Keywords:
p-chloroamphetamine; hyperthermia; 5-HT2 receptor; neurotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, J Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Motoyamakita Machi, Kobe, Hyogo 6588558, Japan Kobe Pharmaceut Univ Motoyamakita Machi Kobe Hyogo Japan 6588558
Citazione:
J. Yamada et al., "Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT in frontal cortex induced by a 5-HT releasing drug, p-chloroamphetamine (PCA) in mice", BIOL PHAR B, 24(10), 2001, pp. 1195-1197

Abstract

Effects of the 5-HT2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT induced by the 5-HT-releasing drug, p-chloroamphetamine (PCA) were investigated. Ritanserin significantly suppressed PCA-induced hyperthermia in mice. PCA elicited decreases in 5-HT levels in the mouse frontal cortex. 5-HT reduction elicited by PCA was also attenuated by pretreatment with ritanserin. Since hyperthermia facilitates neurotoxicity induced by amphetamine analogue, ritanserin may inhibit PCA-induced 5-HT neurotoxicityby inhibiting hyperthermia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:45:43