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Titolo:
Antihypertensive effects of chicken extract against deoxycorticosterone acetate-salt-induced hypertension in rats
Autore:
Matsumura, Y; Okui, T; Ono, H; Kiso, Y; Tanaka, T;
Indirizzi:
Osaka Univ Pharmaceut Sci, Dept Pharmacol, Takatsuki, Osaka 5691094, JapanOsaka Univ Pharmaceut Sci Takatsuki Osaka Japan 5691094 ka 5691094, Japan Cerebos Pacific Ltd, Dept Res & Dev, Singapore 237994, Singapore Cerebos Pacific Ltd Singapore Singapore 237994 ngapore 237994, Singapore Suntory Ltd, Inst Hlth Care Sci, Shimamoto, Osaka 6188503, Japan Suntory Ltd Shimamoto Osaka Japan 6188503 Shimamoto, Osaka 6188503, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 10, volume: 24, anno: 2001,
pagine: 1181 - 1184
SICI:
0918-6158(200110)24:10<1181:AEOCEA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATHOGENESIS; ENDOTHELIUM;
Keywords:
essence of chicken; deoxycorticosterone-salt; hypertension; vascular hypertrophy; renal injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumura, Y Osaka Univ Pharmaceut Sci, Dept Pharmacol, 4-20-1 Nasahara, Takatsuki, Osaka 5691094, Japan Osaka Univ Pharmaceut Sci 4-20-1 Nasahara Takatsuki Osaka Japan 5691094
Citazione:
Y. Matsumura et al., "Antihypertensive effects of chicken extract against deoxycorticosterone acetate-salt-induced hypertension in rats", BIOL PHAR B, 24(10), 2001, pp. 1181-1184

Abstract

We investigated the anti hypertensive effect of Brand's Essence of Chicken(BEC), a popular chicken extract used as a traditional remedy, using deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Animals were unilaterally nephrectomized, and then separated into a sham-operated group (sham group) and a DOCA-salt-treated group. The latter was further separated into anormal diet group and a BEC (freeze-dried powder, 0.1w/w%)-containing dietgroup. Systolic blood pressure of the normal diet group progressively increased in comparison with that of the sham group. The DOCA-salt-induced hypertension was markedly suppressed by feeding a BEC-containing diet. Systolicblood pressure after 5 weeks was 128 +/-2 mmHg in sham group, 181 +/-4 mmHg in the DOCA-salt-treated normal diet group and 139 +/-5 mmHg in the DOCA-salt-treated BEC diet group, respectively. The treatment with DOCA and saltfor 5 weeks significantly increased the weights of heart and left ventricle, but these increases were significantly suppressed in the BEC group. Whenthe degree of vascular hypertrophy of the aorta was histochemically evaluated, DOCA-salt-induced increases in wall thickness and wall area of the vessels were significantly decreased by the BEC-feeding. Histopathological renal damage of fibrinoid-like necrosis in glomeruli, thickening of small arteries and tubular dilatation were observed in the DOCA-salt-treated normal diet group, but this damage was efficiently reduced by the BEC-feeding. In addition, BEC-feeding decreased urinary excretion of protein, which was elevated by the treatment with DOCA and salt. Thus, BEC seems to be useful as aprophylactic treatment in the development of hypertension and related tissue injuries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:48:58