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Titolo:
New strategies for the treatment of Parkinson's disease hold considerable promise for the future management of neurodegenerative disorders
Autore:
Bjarkam, CR; Sorensen, JC; Sunde, NA; Geneser, FA; Ostergaard, K;
Indirizzi:
Univ Aarhus, Inst Anat, Dept Neurobiol, DK-8000 Aarhus C, Denmark Univ Aarhus Aarhus Denmark C , Dept Neurobiol, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp, Dept Neurosurg, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 urosurg, DK-8000 Aarhus, Denmark Aarhus Univ Hosp, Dept Neurol, DK-8000 Aarhus C, Denmark Aarhus Univ HospAarhus Denmark C Dept Neurol, DK-8000 Aarhus C, Denmark
Titolo Testata:
BIOGERONTOLOGY
fascicolo: 3, volume: 2, anno: 2001,
pagine: 193 - 207
SICI:
1389-5729(2001)2:3<193:NSFTTO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEVODOPA-INDUCED DYSKINESIAS; FETAL DOPAMINE NEURONS; INTERMEDIATE THALAMIC NUCLEUS; BASAL GANGLIA; SUBTHALAMIC NUCLEUS; MOVEMENT-DISORDERS; POSTEROVENTRAL PALLIDOTOMY; MESENCEPHALIC TISSUE; FUNCTIONAL-ANATOMY; FOLLOW-UP;
Keywords:
basal ganglia; basal ganglia circuitry; deep brain stimulation; immortalized cell-lines; neural stem cells; neural transplantation; neurotrophic factors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
147
Recensione:
Indirizzi per estratti:
Indirizzo: Bjarkam, CR Univ Aarhus, Inst Anat, Dept Neurobiol, DK-8000 Aarhus C, Denmark Univ Aarhus Aarhus Denmark C biol, DK-8000 Aarhus C, Denmark
Citazione:
C.R. Bjarkam et al., "New strategies for the treatment of Parkinson's disease hold considerable promise for the future management of neurodegenerative disorders", BIOGERONTOL, 2(3), 2001, pp. 193-207

Abstract

Neurodegenerative diseases are often considered incurable with no efficient therapies to modify or halt the progress of disease, and ultimately lead to reduced quality of life and to death. Our knowledge of the nervous system in health and disease has, however, increased considerably during the last fifty years and today, neuroscience reveals promising new strategies to deal with disorders of the nervous system. Some of these results have been implemented with success in the treatment of Parkinson's disease, a common neurodegenerative illness affecting approximately 1% of the population aged seventy or more. Parkinson's disease is characterized by a massive loss of dopaminergic neurons in the substantia nigra, leading to severe functional disturbance of the neuronal circuitry in the basal ganglia. A thorough description of basal ganglia circuitry in health and disease is presented. We describe how the functional disturbances seen in Parkinson's disease may be corrected at specific sites in this circuitry by medical treatment or, in advanced stages of Parkinson's disease, by neurosurgical methods. The latterinclude lesional surgery, neural transplantation and deep brain stimulation, together with future treatment strategies using direct or indirect implantation of genetically modified cell-lines capable of secreting neurotrophic factors or neurotransmitters. Advantages and disadvantages are briefly mentioned for each strategy and the implications for the future and the possible use of these interventions in other neurodegenerative diseases are discussed, with special emphasis on deep brain stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:38:40