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Titolo:
Neoplastic disease through the human life span
Autore:
Macieira-Coelho, A;
Titolo Testata:
BIOGERONTOLOGY
fascicolo: 3, volume: 2, anno: 2001,
pagine: 179 - 192
SICI:
1389-5729(2001)2:3<179:NDTTHL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER RISK; TESTICULAR CANCER; AGE DISTRIBUTION; OLD MICE; GROWTH; FIBROBLASTS; MELANOMA; CELLS; IMMORTALIZATION; CARCINOMA;
Keywords:
cancer heterogeneity; cancer incidence; cancer progression; chemical carcinogens; oncogenes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Macieira-Coelho, A 73 Bir Rue Marechal Foch, F-78000 Versailles, France 73 Bir Rue Marechal Foch Versailles France F-78000 ce
Citazione:
A. Macieira-Coelho, "Neoplastic disease through the human life span", BIOGERONTOL, 2(3), 2001, pp. 179-192

Abstract

Cancers are different diseases that start and evolve each in its own manner, and trigger variable responses from the organism depending upon the neoplastic process under way and upon the physiopathology of the organism. The clinical incidence of the different cancers is spread through the human life span, with regional differences for each cancer; for many cancers the incidence is increasing at younger ages. More than half of the cancers become clinically manifest during the second half of the human life span and theirfrequency increases with age, but their natural history starts way back atearlier ages. The data suggest that the late manifestation is the result of the accumulation of events through time rather than of aging. Interestingly, late in the human life span the incidence of neoplastic disease declines. Is this due to the cohort of late survivals naturally resistant to the development of neoplastic processes, or to the characteristics of the last 'window' of the human life span? The evolution of neoplastic disease is the result of pre- and postnatal aggressions suffered by the organism, individual susceptibility, and developmental changes that evolve continuously from the beginning to the end of the human life span. The identification of the causes of the incidences of the different cancers through the human life span will help to understand both neoplastic disease and aging of the organism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:09:38