Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
On the "struggle between chemistry and biology during aging" - implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention
Autore:
Hipkiss, AR;
Indirizzi:
Univ London Kings Coll, Div Biomol Sci, Sch Biomed Sci, GKT, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL T, London SE1 1UL, England
Titolo Testata:
BIOGERONTOLOGY
fascicolo: 3, volume: 2, anno: 2001,
pagine: 173 - 178
SICI:
1389-5729(2001)2:3<173:OT"BCA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENESCENCE-ACCELERATED MICE; HUMAN-DIPLOID FIBROBLASTS; DIPEPTIDE L-CARNOSINE; AGE-RELATED-CHANGES; ALPHA-A-CRYSTALLIN; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; PROTEIN OXIDATION; ASPARTYL RESIDUES; ANTIAGING PEPTIDE;
Keywords:
aberrant proteins; ageing; caspase; deamidation; DNA repair; isoaspartate; proteolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Hipkiss, AR Univ London Kings Coll, Div Biomol Sci, Sch Biomed Sci, GKT, Henriette Raphael House,London Bridge, London SE1 1UL, England Univ London Kings Coll Henriette Raphael House,London Bridge London England SE1 1UL
Citazione:
A.R. Hipkiss, "On the "struggle between chemistry and biology during aging" - implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention", BIOGERONTOL, 2(3), 2001, pp. 173-178

Abstract

The possible effects of specific spontaneous changes in protein chemistry on age-related homeostatic dysfunction are discussed. Spontaneous racemization and isomerization of aspartic acid and deamidation of asparagine to four possible forms of aspartic acid in caspases and their substrates could profoundly alter apoptotic activity. Deamidation of asparagine residues at critically important sites of DNA glycosylases could compromise base excisionrepair activity. Furthermore, as oxidative damage may enhance asparagine/aspartate instability in proteins, and erroneously-synthesized proteins showincreased susceptibility to oxidative attack, it is beginning to appear that the aberrant protein forms that accumulate during ageing are possibly interrelated. The role of cell growth rates in controlling constitutive proteolytic elimination of various forms of aberrant polypeptides is then discussed. Finally, it is pointed out that three recently described agents that delay senescence in cultured cells (aminoguanidine, N-t-butylhydroxylamine and kinetin) resemble carnosine in that they are also likely to react with glycoxidised proteins, as well as possess anti-oxidant activity. These observations suggest that pluripotency may be a necessary pre-requisite for effective anti-ageing activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:30:07