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Titolo:
Influence of alternating low frequency magnetic fields on reactivity of central dopamine receptors in neonatal 6-hydroxydopamine treated rats
Autore:
Sieron, A; Brus, R; Szkilnik, R; Plech, A; Kubanski, N; Cieslar, G;
Indirizzi:
Silesian Med Univ, Chair & Clin Internal Dis & Phys Med, Zabrze, Poland Silesian Med Univ Zabrze Poland Internal Dis & Phys Med, Zabrze, Poland Silesian Med Univ, Chair & Dept Pharmacol, Zabrze, Poland Silesian Med Univ Zabrze Poland Chair & Dept Pharmacol, Zabrze, Poland
Titolo Testata:
BIOELECTROMAGNETICS
fascicolo: 7, volume: 22, anno: 2001,
pagine: 479 - 486
SICI:
0197-8462(200110)22:7<479:IOALFM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
WEAK ELECTROMAGNETIC-FIELDS; PARKINSONS-DISEASE; BEHAVIOR; REVERSAL; BRAIN; MICE;
Keywords:
ELF magnetic field; SKF 38393 induced oral activity; SCH 23390 induced catalepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sieron, A Silesian Med Univ, Chair & Clin Internal Dis & Phys Med, Batory St 15, PL-41902 Bytom, Poland Silesian Med Univ Batory St 15 Bytom Poland PL-41902 om, Poland
Citazione:
A. Sieron et al., "Influence of alternating low frequency magnetic fields on reactivity of central dopamine receptors in neonatal 6-hydroxydopamine treated rats", BIOELECTROM, 22(7), 2001, pp. 479-486

Abstract

The aim of this study was to evaluate the influence of extremely low frequency magnetic field (ELF MF) on the reactivity of the central dopamine D-1 receptor in rats with dopamine neurons chemically damaged by 6-hydroxydopamine (6-OHDA), an animal model of human's Parkinson's disease. The experiment was carried out on male Wistar rats. On day 3 of postnatal life, a lasting and selective chemical damage of the central dopamine system was induced in the rats by infusion of 6-OHDA HBr (133.4 mug intracerebroventricular, base form) given bilaterally into lateral ventricles of the brain. Control animals received similar treatments injecting only vehicle. At 2 months of age, both 6-OHDA treated and control rats were randomly divided into two groups. Rats from the first group were exposed to 10 Hz sinusoidal, 1.8-3.8 mTmagnetic field one hour daily for 14 days. Rats of the second group were sham exposed, with the applicator solenoid tamed off. On the day after the final exposure the evaluations were made of the rat's spontaneous irritability, oral activity, and catalepsy. The MF exposed rat with chemically induced dopamine neurons damage exhibited a reduction of irritability and oral activity when stimulated with SKF 38393 (the agonist of central dopamine D-1 receptor) and some increase of catalepsy after administration of SCH 23390 (the antagonist of central doparnine D-1 receptor). These results indicate that ELF MF reduce the reactivity of central dopamine D-1 receptors in rats. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:05:00