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Titolo:
Induction of SPARC by VEGF in human vascular endothelial cells
Autore:
Kato, Y; Lewalle, JM; Baba, Y; Tsukuda, M; Sakai, N; Baba, M; Kobayashi, K; Koshika, S; Nagashima, Y; Frankenne, F; Noel, A; Foidart, JM; Hata, RI;
Indirizzi:
Kanagawa Dent Coll, Dept Biochem & Mol Biol, Bioventure Res Ctr, Yokosuka,Kanagawa 2388580, Japan Kanagawa Dent Coll Yokosuka Kanagawa Japan 2388580anagawa 2388580, Japan Kanagawa Dent Coll, Div Gene Regulat, Bioventure Res Ctr, Yokosuka, Kanagawa 2388580, Japan Kanagawa Dent Coll Yokosuka Kanagawa Japan 2388580 anagawa 2388580, Japan Univ Liege, Fac Med, Lab Tumor & Dev Biol, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 Tumor & Dev Biol, B-4000 Liege, Belgium Yokohama City Univ, Sch Med, Dept Pathol, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Kanagawa Dent Coll, Bioventure Res Ctr, Div Gene Regulat, Yokosuka, Kanagawa 2388580, Japan Kanagawa Dent Coll Yokosuka Kanagawa Japan 2388580 anagawa 2388580, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 287, anno: 2001,
pagine: 422 - 426
SICI:
0006-291X(20010921)287:2<422:IOSBVI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BREAST-CANCER; GROWTH-FACTOR; NEOPLASTIC PROGRESSION; MATRIX PROTEINS; CYSTEINE SPARC; HUMAN-MELANOMA; EXPRESSION; MIGRATION; ANGIOGENESIS; OSTEONECTIN;
Keywords:
endothelial cells; SPARC/osteonectin/BM-40; angiogenesis; VEGF; MAP kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, Y Kanagawa Dent Coll, Dept Biochem & Mol Biol, Bioventure Res Ctr, 82 InaokaCho, Yokosuka, Kanagawa 2388580, Japan Kanagawa Dent Coll 82 InaokaCho Yokosuka Kanagawa Japan 2388580 n
Citazione:
Y. Kato et al., "Induction of SPARC by VEGF in human vascular endothelial cells", BIOC BIOP R, 287(2), 2001, pp. 422-426

Abstract

SPARC/osteonectin/BM-40 is a matricellular protein that is thought to be involved in angiogenesis and endothelial barrier function. Previously, we have detected high levels of SPARC expression in endothelial cells (ECs) adjacent to carcinomas of kidney and tongue. Although SPARC-derived peptide showed an angiogenic effect, intact SPARC itself inhibited the mitogenic activity of vascular endothelial growth factor (VEGF) for ECs by the inhibiting phosphorylation of flt-1 (VEGF receptor 1) and subsequent ERK activation. Thus, the role of SPARC in tumor angiogenesis, stimulation or inhibition, isstill unclear. To clarify the role of SPARC in tumor growth and progression, we determined the effect of VEGF on the expression of SPARC in human microvascular EC line, HMEC-1, and human umbilical vein ECs. VEGF increased the levels of SPARC protein and steady-state levels of SPARC mRNA in serum-starved HMEC-1 cells. Inhibitors (SE202190 and SB203580) of p38, a mitogen-activated protein (MAP) kinase, attenuated VEGF-stimulated SPARC production in ECs. Since intact SPARC inhibits phosphorylation ERK MAP kinase in VEGF signaling, it was suggested that SPARC plays a dual role in the VEGF functions, tumor angiogenesis, and extravasation of tumors mediated by the increased permeability of endothelial barrier function. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:58:08