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Titolo:
Genetics of human obesity
Autore:
Boutin, P; Froguel, P;
Indirizzi:
Inst Pasteur, CNRS, Inst Biol Lille, F-59019 Lille, France Inst Pasteur Lille France F-59019 Inst Biol Lille, F-59019 Lille, France Univ London Queen Mary & Westfield Coll, London E1 4NS, England Univ London Queen Mary & Westfield Coll London England E1 4NS S, England St Bartholomews Hosp, London Genome Ctr, London, England St Bartholomews Hosp London England London Genome Ctr, London, England
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
fascicolo: 3, volume: 15, anno: 2001,
pagine: 391 - 404
SICI:
1521-690X(200109)15:3<391:GOHO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY-ONSET OBESITY; HUMAN OB GENE; BETA-3-ADRENERGIC RECEPTOR GENE; CONGENITAL LEPTIN DEFICIENCY; TYPE-2 DIABETES-MELLITUS; QUANTITATIVE TRAIT LOCUS; BODY-MASS INDEX; LINKAGE DISEQUILIBRIUM; UNCOUPLING PROTEIN; MORBID-OBESITY;
Keywords:
genetics; obesity; multifactorial disease; leptin; leptin receptor; POMC; MC4R; genome-wide scans; susceptibility genes for obesity; positional cloning; linkage studies; association studies; linkage disequilibrium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Boutin, P Inst Pasteur, CNRS, Inst Biol Lille, F-59019 Lille, France Inst Pasteur Lille France F-59019 Lille, F-59019 Lille, France
Citazione:
P. Boutin e P. Froguel, "Genetics of human obesity", BEST PRAC R, 15(3), 2001, pp. 391-404

Abstract

Obesity is a multifactorial condition. Environmental risk factors related to a sedentary lifestyle and unlimited access to food apply constant pressure in subjects with a genetic predisposition to gain weight. The fact that genetic defects can result in human obesity has been unequivocally established over the past 3 years with the identification of the genetic defects responsible for different monogenic forms of human obesity: the leptin, leptin receptor, pro-opiomelanocortin, pro-hormone convertase-1 and melanocortin-4 receptor genes. The common forms of obesity are, however, polygenic. Theexamination of specific genes for involvement in the susceptibility to common obesity has not yet yielded convincing results. Approaches involving the candidate genes and the positional cloning of major obesity-linked regions (state-of-the-art future prospects) will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/12/19 alle ore 12:17:32