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Titolo:
The genetics of type 2 diabetes
Autore:
Gloyn, AL; McCarthy, MI;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Imperial Coll Genet,London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland Univ London Imperial Coll Sci Technol & Med, Sch Med, Genom Res Inst, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland Univ London Imperial Coll Sci Technol & Med, Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med LondonEngland W12 0NN gland
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
fascicolo: 3, volume: 15, anno: 2001,
pagine: 293 - 308
SICI:
1521-690X(200109)15:3<293:TGOT2D>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RECEPTOR SUBSTRATE-1; AMINO-ACID POLYMORPHISM; GENOME-WIDE SEARCH; LOW-BIRTH-WEIGHT; SUSCEPTIBILITY LOCUS; MITOCHONDRIAL-DNA; THRIFTY PHENOTYPE; SEQUENCE VARIANTS; GLUCOSE-TOLERANCE; COMPLEX TRAITS;
Keywords:
genetics; type 2 diabetes; association studies; candidate genes; genome-wide scans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: McCarthy, MI Univ London Imperial Coll Sci Technol & Med, Sch Med, Imperial Coll Genet,Hammersmith Campus,Du Cane Rd, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med Hammersmith Campus,Du Cane Rd London England W12 0NN
Citazione:
A.L. Gloyn e M.I. McCarthy, "The genetics of type 2 diabetes", BEST PRAC R, 15(3), 2001, pp. 293-308

Abstract

Type 2 diabetes mellitus is not a single disease but a genetically heterogenous group of metabolic disorders sharing glucose intolerance. The preciseunderlying biochemical defects are unknown and almost certainly include impairments of both insulin secretion and action. The rapidly increasing prevalence of T2D world wide makes it a major cause of morbidity and mortality. Understanding the genetic aetiology of T2D will facilitate its diagnosis, treatment and prevention. The results of linkage and association studies todate demonstrate that, as with other common diseases, multiple genes are involved in the susceptibility to T2D, each making a modest contribution to the overall risk. The completion of the draft human genome sequence and a brace of novel tools for genomic analysis promise to accelerate progress towards a more complete molecular description of T2D.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/12/19 alle ore 15:09:21