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Titolo:
An overview of the genetic analysis of complex diseases, with reference totype I diabetes
Autore:
Thomson, G;
Indirizzi:
Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA Univ CalifBerkeley Berkeley CA USA 94720 at Biol, Berkeley, CA 94720 USA
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
fascicolo: 3, volume: 15, anno: 2001,
pagine: 265 - 277
SICI:
1521-690X(200109)15:3<265:AOOTGA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE DISEQUILIBRIUM; SUSCEPTIBILITY GENES; PREDISPOSING VARIANTS; ALLELIC ASSOCIATION; MULTIPLE-SCLEROSIS; HAPLOTYPE METHOD; HUMAN GENOME; MELLITUS; INHERITANCE; FAMILIES;
Keywords:
linkage; association; HLA; disease genes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Thomson, G Univ Calif Berkeley, Dept Integrat Biol, 3060 Valley Life Sci Bldg, Berkeley, CA 94720 USA Univ Calif Berkeley 3060 Valley Life Sci Bldg Berkeley CA USA 94720
Citazione:
G. Thomson, "An overview of the genetic analysis of complex diseases, with reference totype I diabetes", BEST PRAC R, 15(3), 2001, pp. 265-277

Abstract

Despite extensive efforts by many groups, progress in the mapping of complex diseases has been exceedingly slow, only a few genes and some genetic regions having been identified. The general picture is one of difficulty in locating disease genes and in the replication of linkages. This results fromthe role in disease of a large number of genes, many with a relatively minor effect and many involving common genetic variation. A multi-strategy approach to the mapping of complex diseases is required: no single method is sufficient or optimal. The role of human leukocyte antigens in type 1 diabetes has been known for nearly 30 years, and the associations, linkage and genetic contribution to disease are all strong, but all the human leukocyte antigen region genes involved in the disease process have not yet been identified. The methods used in study of this component to type 1 diabetes are amodel for all complex diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/12/19 alle ore 03:56:56