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Titolo:
Conditioning of ictal and interictal behaviors in rats by amygdala kindling: Context as the conditional stimulus
Autore:
Barnes, SJ; Pinel, JPJ; Francis, LH; Wig, GS;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 5, volume: 115, anno: 2001,
pagine: 1065 - 1072
SICI:
0735-7044(200110)115:5<1065:COIAIB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEAR-POTENTIATED STARTLE; ELECTRICAL STIMULATION; INDUCED EPILEPSY; SEIZURE ACTIVITY; CONSEQUENCES; SENSITIZATION; EMOTIONALITY; ANXIETY; COCAINE; STATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Barnes, SJ Univ British Columbia, Dept Psychol, 2136 W Mall,Room 2509, Vancouver, BC V6T 1Z4, Canada Univ British Columbia 2136 W Mall,Room 2509 Vancouver BC Canada V6T 1Z4
Citazione:
S.J. Barnes et al., "Conditioning of ictal and interictal behaviors in rats by amygdala kindling: Context as the conditional stimulus", BEHAV NEURO, 115(5), 2001, pp. 1065-1072

Abstract

The authors showed that conditional effects of the stimulation environmentmodulate both the ictal and interictal behaviors of rats subjected to amygdala kindling. Rats received 53 stimulations to the left basolateral amygdala in 1 conditional stimulus (CS) context (CS+) and 53 sham stimulations (the stimulation lead was attached but no current was delivered) in another context (CS-), quasirandomly over 54 days. Three kinds of conditional effects were observed. First, after several stimulations, less ambulatory activity, more freezing, and less rearing reliably occurred in the CS+ context than in the CS context. Second, after 45 stimulations, all of the rats chose the CS- context over the CS+ context in a conditioned place preference test. Third, when the rats were finally stimulated in the CS- context, their motor seizures were less severe: Latencies were longer, motor seizures were shorter, convulsive patterns were of a lower class, and there were fewer falls.

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Documento generato il 03/04/20 alle ore 13:47:46