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Titolo:
The effect of three different doses of sodium pentosan polysulphate on haematological and haemostatic variables in adult horses
Autore:
Dart, AJ; Perkins, N; Dowling, BA; Batterham, T; Livingston, C; Hodgson, DR;
Indirizzi:
Univ Sydney, Dept Vet Clin Sci, Univ Vet Ctr Camden, Camden, NSW 2570, Australia Univ Sydney Camden NSW Australia 2570 Camden, Camden, NSW 2570, Australia
Titolo Testata:
AUSTRALIAN VETERINARY JOURNAL
fascicolo: 9, volume: 79, anno: 2001,
pagine: 624 - 627
SICI:
0005-0423(200109)79:9<624:TEOTDD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFATED POLYSACCHARIDES; CYTOKINE PRODUCTION; POLYSULFATE SP54; HEPARIN; OSTEOARTHRITIS; INTERLEUKIN-4;
Keywords:
sodium pentosan polysulphate; horse; equine; haematology; haemostasis; anticoagulant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Dart, AJ Univ Sydney, Dept Vet Clin Sci, Univ Vet Ctr Camden, Werombi Rd, Camden, NSW 2570, Australia Univ Sydney Werombi Rd Camden NSW Australia 2570 2570, Australia
Citazione:
A.J. Dart et al., "The effect of three different doses of sodium pentosan polysulphate on haematological and haemostatic variables in adult horses", AUST VET J, 79(9), 2001, pp. 624-627

Abstract

Objective To evaluate the effects of three different doses of sodium pentosan polysulphate (PPS) on haematological and haemostatic variables in adulthorses. Design Eight adult standardbred horses were used. All horses received a single injection of 0, 3, 6, and 10 mg/kg of PPS at the beginning of each treatment week for 4 weeks so that by the end of the study all horses had received all four doses of PPS. Blood samples were collected at 0, 1, 2, 3, 4, 6, 8, 12, 24, 48, and 168 h after each weekly injection of PPS. Variables measured were packed cell volume, haemoglobin, red blood cell count, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, platelet count, white cell count, neutrophil count, lymphocyte count, eosinophil count, monocyte count, serum protein, fibrinogen, prothrombin time, and activated partial thromboplastin time (PTT). Data were analysed using an ANOVA. Significance was set at P < 0.05. Results There was a dose-dependent increase in PTT. A significant increasein PTT occurrred in all treatment groups when compared to horses receiving0 mg/kg in which there was no change over time. The PTT values all returned to baseline by 48 h after treatment. The mean neutrophil count was higher3 h after treatment when compared to time 0. Horses receiving 3 mg/kg of PPS had a higher lymphocyte count 4 h after injection, and those receiving 6and 10 mg/kg had higher counts at 3,4,6 and 8 h after injection when compared to time 0. At 8 h after injection horses receiving 6 and 10 mg PPS had higher lymphocyte counts than horses not receiving PPS. Conclusions PPS causes a dose-dependent prolongation of PTT in horses. At the dose rates currently recommended for treatment of joint problems in horses this increase was small and remained elevated from baseline for up to 24 h. Based on these findings doses of PPS up to 3 mg/kg should not be administered to horses within 24 h of high stress activities or where physical injury may occur.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:20:32