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Titolo:
Differentiation of monocytes into multinucleated giant bone-resorbing cells: two-step differentiation induced by nurse-like cells and cytokines
Autore:
Toyosaki-Maeda, T; Takano, H; Tomita, T; Tsuruta, Y; Maeda-Tanimura, M; Shimaoka, Y; Takahashi, T; Itoh, T; Suzuki, R; Ochi, T;
Indirizzi:
Osaka Univ, Sch Med, Dept Orthoped Surg, Osaka 5660871, Japan Osaka Univ Osaka Japan 5660871 Dept Orthoped Surg, Osaka 5660871, Japan Shionogi & Co Ltd, Shionogi Res Labs, Dept Immunol, Osaka 553, Japan Shionogi & Co Ltd Osaka Japan 553 s Labs, Dept Immunol, Osaka 553, Japan Kyushu Dent Coll, Sch Dent, Dept Oral Surg, Kitakyushu, Fukuoka 803, JapanKyushu Dent Coll Kitakyushu Fukuoka Japan 803 akyushu, Fukuoka 803, Japan Tohoku Univ, Sch Med, Dept Immunoontogeny, Aoba Ku, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 y, Aoba Ku, Sendai, Miyagi 980, Japan
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 5, volume: 3, anno: 2001,
pagine: 306 - 310
SICI:
1465-9913(2001)3:5<306:DOMIMG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHEUMATOID-ARTHRITIS; OSTEOCLAST DIFFERENTIATION; DENDRITIC CELLS; BLOOD MONOCYTES; STROMAL CELLS; RESORPTION; ESTABLISHMENT; SYNOVIUM; THYMOCYTES; EXPRESSION;
Keywords:
monocytes; nurse cells; osteoclasts; rheumatoid arthritis; stromal cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ochi, T Osaka Univ, Sch Med, Dept Orthoped Surg, Yamada Oka 2-2, Osaka 5660871, Japan Osaka Univ Yamada Oka 2-2 Osaka Japan 5660871 saka 5660871, Japan
Citazione:
T. Toyosaki-Maeda et al., "Differentiation of monocytes into multinucleated giant bone-resorbing cells: two-step differentiation induced by nurse-like cells and cytokines", ARTHRITIS R, 3(5), 2001, pp. 306-310

Abstract

Bone resorption in the joints is the characteristic finding in patients with rheumatoid arthritis (RA). Osteoclast-like cells are present in the synovial tissues and invade the bone of patients with RA. The characteristics of these cells are not completely known. In the work reported here, we generated these cells from peripheral-blood monocytes from healthy individuals. The monocytes were co-cultured with nurse-like cells from synovial tissues of patients with RA (RA-NLCs). Within 5 weeks of culture, the monocytes were activated and differentiated into mononuclear cells positive for CD14 andtartrate-resistant acid phosphatase (TRAP). These mononuclear cells then differentiated into multinucleated giant bone-resorbing cells after stimulation with IL-3, IL-5, IL-7, and/or granulocyte-macrophage-colony-stimulatingfactor. TRAP-positive cells with similar characteristics were found in synovial fluid from patients with RA. These results indicate that multinucleated giant bone-resorbing cells are generated from monocytes in two steps: first, RA-NLCs induce monocytes to differentiate into TRAP-positive mononuclear cells, which are then induced by cytokines to differentiate into multinucleated giant bone-resorbing cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:39:34