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Titolo:
Genetic markers of osteoarticular disorders: facts and hopes
Autore:
Brandi, ML; Gennari, L; Cerinic, MM; Becherini, L; Falchetti, A; Masi, L; Gennari, C; Reginster, JY;
Indirizzi:
Univ Florence, Dept Med, I-50135 Florence, Italy Univ Florence Florence Italy I-50135 , Dept Med, I-50135 Florence, Italy Univ Florence, Rheumatol Sect, Florence, Italy Univ Florence Florence Italy Florence, Rheumatol Sect, Florence, Italy Univ Siena, Inst Internal Med, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 , Inst Internal Med, I-53100 Siena, Italy Univ Liege, Bone & Articular Cartilage Res Unit, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 artilage Res Unit, B-4000 Liege, Belgium
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 5, volume: 3, anno: 2001,
pagine: 270 - 280
SICI:
1465-9913(2001)3:5<270:GMOODF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D-RECEPTOR; BONE-MINERAL-DENSITY; POSTMENOPAUSAL ITALIAN WOMEN; SP1 BINDING-SITE; TRANSLATION INITIATION SITE; START CODON POLYMORPHISM; LIFE-STYLE FACTORS; I ALPHA-1 GENE; ESTROGEN-RECEPTOR; PREMENOPAUSAL WOMEN;
Keywords:
candidate genes; genetics; multifactorial diseases; osteoporosis; osteoarthritis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
141
Recensione:
Indirizzi per estratti:
Indirizzo: Brandi, ML Univ Florence, Dept Med, Viale Morgagni 85, I-50135 Florence, Italy Univ Florence Viale Morgagni 85 Florence Italy I-50135 , Italy
Citazione:
M.L. Brandi et al., "Genetic markers of osteoarticular disorders: facts and hopes", ARTHRITIS R, 3(5), 2001, pp. 270-280

Abstract

Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders are inversely related. Thus, an accurate analysis of the genetic component of one of these two multifactorial diseases may provide data of interest for the other. However, the existence of confounding factors must always be borne in mind in interpreting the genetic analysis. In addition, each patient must be given an accurate clinical evaluation, including family history, history of drug treatments, lifestyle, and environment, in order to reduce the background bias. Here, we review the impact of recent work in molecular genetics suggesting that powerful molecular biology techniques will soon make possible both a rapid accumulation of data on the genetics of both disorders and the development of novel diagnostic, prognostic, and therapeutic approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:10:18