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Titolo:
Transmission of Mycobacterium tuberculosis through casual contact with an infectious case
Autore:
Golub, JE; Cronin, WA; Obasanjo, OO; Coggin, W; Moore, K; Pope, DS; Thompson, D; Sterling, TR; Harrington, S; Bishai, WR; Chaisson, RE;
Indirizzi:
Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21231 USAJohns Hopkins Univ Baltimore MD USA 21231 demiol, Baltimore, MD 21231 USA Johns Hopkins Univ, Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21231 USA Johns Hopkins Univ Baltimore MD USA 21231 t Hlth, Baltimore, MD 21231 USA Maryland Dept Hlth & Mental Hyg, Baltimore, MD 21202 USA Maryland Dept Hlth & Mental Hyg Baltimore MD USA 21202 more, MD 21202 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 pt Med, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pathol, Baltimore, MD 21205 USA Baltimore City Dept Hlth, Baltimore, MD USA Baltimore City Dept Hlth Baltimore MD USA y Dept Hlth, Baltimore, MD USA
Titolo Testata:
ARCHIVES OF INTERNAL MEDICINE
fascicolo: 18, volume: 161, anno: 2001,
pagine: 2254 - 2258
SICI:
0003-9926(20011008)161:18<2254:TOMTTC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIRECTLY OBSERVED THERAPY; EXOGENOUS REINFECTION; OUTBREAK; EPIDEMIOLOGY; VIRULENT; CDC1551; STRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Chaisson, RE Johns Hopkins Univ, Sch Publ Hlth, Dept Med, 424 N Bond St, Baltimore, MD 21231 USA Johns Hopkins Univ 424 N Bond St Baltimore MD USA 21231 1 USA
Citazione:
J.E. Golub et al., "Transmission of Mycobacterium tuberculosis through casual contact with an infectious case", ARCH IN MED, 161(18), 2001, pp. 2254-2258

Abstract

Background: An ongoing restriction fragment length polymorphism study of Mycobacterium tuberculosis isolates from tuberculosis cases showed an identical 12-band IS6110 pattern unique to 3 unrelated patients (Patients A-C) diagnosed as having tuberculosis within a 9-month period. Methods: In an attempt to identify epidemiologic links between the 3 patients, we performed site visits to the retail business work site of patient Aand conducted detailed interviews with all 3 patients and their contacts. Results: Patient B had visited patient A's work site 3 times during patient A's infectious period, spending no more than 15 minutes each time. Patient C visited patient A's work site on 6 to 10 occasions during this period for no more than 45 minutes at any one time. There were no other epidemiologic links between these 3 cases other than the contact at the store. Contactinvestigation identified 4 tuberculin skin test conversions among 8 (50%) of patient A's coworkers, 6 positive tests among 15 household contacts (40%), and 8 positive tests among 16 identified customers who were casual contacts (50%). Patient B and patient C were most likely infected by patient A during one of their brief visits to patient A's work site. Conclusions: These data demonstrate that some tuberculosis is spread through casual contact not normally pursued in traditional contact investigations and that, in certain situations, M tuberculosis can be transmitted despite minimal duration of exposure. In addition, this outbreak emphasizes the importance of DNA fingerprinting data for identifying unusual transmission in unexpected settings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:34:09