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Titolo:
The human repertoire of odorant receptor genes and pseudogenes
Autore:
Mombaerts, P;
Indirizzi:
Rockefeller Univ, New York, NY 10021 USA Rockefeller Univ New York NY USA10021 eller Univ, New York, NY 10021 USA
Titolo Testata:
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
, volume: 2, anno: 2001,
pagine: 493 - 510
SICI:
1527-8204(2001)2:<493:THROOR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE OLFACTORY RECEPTOR; SENSITIVE ADENYLATE-CYCLASE; MAMMALIAN TASTE RECEPTORS; FUNCTIONAL EXPRESSION; MOLECULAR-BIOLOGY; XENOPUS-LAEVIS; HUMAN GENOME; GERM-CELLS; FAMILY; MOUSE;
Keywords:
olfaction; smell; odor; olfactory; nose;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Mombaerts, P Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA Rockefeller Univ 1230 York Ave New York NY USA 10021 0021 USA
Citazione:
P. Mombaerts, "The human repertoire of odorant receptor genes and pseudogenes", ANN REV GEN, 2, 2001, pp. 493-510

Abstract

The nose of Homo sapiens is a sophisticated chemical sensor. It is able tosmell almost any type of volatile molecule, often at extraordinarly low concentrations, and can make fine perceptual discriminations between structurally related molecules. The diversity of odor recognition is mediated by odorant receptor (OR) genes, discovered in 1991 by Buck & Axel. OR genes formthe largest gene families in mammalian genomes. A decade after their discovery, advances in the sequencing of the human genome have provided a first draft of the human OR repertoire: It consists of similar to 1000 sequences,residing in multiple clusters spread throughout the genome, with more thanhalf being pseudogenes. Allelic variants are beginning to be recognized and may provide an opportunity for genotype-phenotype correlations. Here, I review the current knowledge of the human OR repertoire and summarize the limited information available regarding putative pheromone and taste receptors in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:05:10