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Titolo:
ENU mutagenesis: Analyzing gene function in mice
Autore:
Balling, R;
Indirizzi:
German Res Ctr Biotechnol, D-38124 Braunschweig, Germany German Res Ctr Biotechnol Braunschweig Germany D-38124 nschweig, Germany
Titolo Testata:
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
, volume: 2, anno: 2001,
pagine: 463 - 492
SICI:
1527-8204(2001)2:<463:EMAGFI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC STEM-CELLS; ETHYL-N-NITROSOUREA; IN-VITRO FERTILIZATION; MOUSE SPERMATOZOA; INDUCED MUTATIONS; LOCUS MUTATIONS; LETHAL MUTATIONS; CRYOPRESERVED SPERMATOZOA; INTESTINAL NEOPLASIA; RELEVANT PHENOTYPES;
Keywords:
mouse genetics; functional genomics; ethlynitrosourea; phenotyping; screening;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Balling, R German Res Ctr Biotechnol, D-38124 Braunschweig, Germany GermanRes Ctr Biotechnol Braunschweig Germany D-38124 ermany
Citazione:
R. Balling, "ENU mutagenesis: Analyzing gene function in mice", ANN REV GEN, 2, 2001, pp. 463-492

Abstract

With the completion of the human genome, sequence analysis of gene function will move into the center of future genome research. One of the key strategies for studying gene function involves the genetic dissection of biological processes in animal models. Mouse mutants are of particular importance for the analysis of disease pathogenesis and transgenic techniques, and gene targeting have become routine tools. Recently, phenotype-driven strategies using chemical mutagenesis have been the target of increasing interest. In this review, the current state of ENU mutagenesis and its application as a systematic tool of genome analysis are examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 21:58:28