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Titolo:
Jugular bulb oxyhemoglobin desaturation, S100 beta, and neurologic and cognitive outcomes after coronary artery surgery
Autore:
Robson, MJA; Alston, RP; Deary, IJ; Andrews, PJD; Souter, MJ;
Indirizzi:
St Vincents Hosp, Dept Anaesthesia, Melbourne, Vic, Australia St Vincents Hosp Melbourne Vic Australia esia, Melbourne, Vic, Australia Univ Edinburgh, Dept Clin & Surg Sci, Dept Anaesthesia, Crit Care & Pain Med Sect, Edinburgh EH8 9YL, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9YL Midlothian, Scotland Royal Infirm, Dept Anaesthesia, Edinburgh, Midlothian, Scotland Royal Infirm Edinburgh Midlothian Scotland inburgh, Midlothian, Scotland Univ Edinburgh, Dept Psychol, Edinburgh EH8 9YL, Midlothian, Scotland UnivEdinburgh Edinburgh Midlothian Scotland EH8 9YL Midlothian, Scotland Western Gen Hosp, Dept Anaesthesia, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland So Gen Hosp, Dept Neuroanaesthesia, Glasgow G51 4TF, Lanark, Scotland So Gen Hosp Glasgow Lanark Scotland G51 4TF gow G51 4TF, Lanark, Scotland
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 4, volume: 93, anno: 2001,
pagine: 839 - 845
SICI:
0003-2999(200110)93:4<839:JBODSB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; CARDIOPULMONARY BYPASS; CARDIAC-SURGERY; RISK-FACTORS; S-100 PROTEIN; BRAIN INJURY; SATURATION; STROKE; COMPLICATIONS; DYSFUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Robson, MJA St Vincents Hosp, Dept Anaesthesia, 41 Victoria Parade, Fitzroy, Vic 3065,Australia St Vincents Hosp 41 Victoria Parade Fitzroy Vic Australia 3065
Citazione:
M.J.A. Robson et al., "Jugular bulb oxyhemoglobin desaturation, S100 beta, and neurologic and cognitive outcomes after coronary artery surgery", ANESTH ANAL, 93(4), 2001, pp. 839-845

Abstract

We reported that a decline in cognitive performance 3 mo after coronary artery bypass grafting surgery is associated with palpable aortic atheroma, but not postoperative jugular bulb oxyhemoglobin saturation (Sjo(2)) < 50%. However, the effect of Sjo(2) on clinical neurologic findings is not known. S100 beta is a possible surrogate biochemical marker of brain injury, and we report here the scored clinical neurologic findings in 98 patients from our previous study in relation to Sjo(2), cognitive performance, aortic atheroma, and S100 beta. Patients underwent a scored neurologic examination and cognitive assessment the day before and 3 mo after coronary artery bypassgrafting surgery. Intraoperatively, intermittent blood sampling was performed, and postoperatively, the area under the curve describing Sjo(2) < 50% in relation to time was calculated from continuous jugular bulb reflectanceoximetry. Palpation was used to assess the ascending aorta for the presence of atheroma. The jugular bulb concentration of S100 beta was measured 6 hafter completion of surgery. The neurologic score 3 mo after surgery did not correlate with either intra- or postoperative Sjo(2) (r = 0.111, P = 0.278; and r = -0.074, P = 0.467, respectively). The main determinant of neurologic score at 3 mo was the preoperative neurologic score (r(2) = 0.63, P <0.001), whereas palpable atheroma of the ascending aorta made a small but significant contribution (r(2) = 0.034, P = 0.004). Neurologic and cognitive scores correlated before surgery (r = 0.226, P = 0.022) and at 3 me aftersurgery (r = 0.348, P < 0.001). A preoperative neurologic deficit of two or more had a small but significant negative effect on cognitive performanceat 3 mo (standardized beta = -0.097, P = 0.018). There was a significant univariate correlation between S100 beta and the 3-mo neurologic score (r = -0.232, P < 0.05), but not a multivariate correlation (beta = -0.090, P = 0.156).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 11:02:30