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Titolo:
Molecular neurobiology of addiction
Autore:
Nestler, EJ;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 d Ctr, Dept Psychiat, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 , Ctr Basic Neurosci, Dallas, TX 75390 USA
Titolo Testata:
AMERICAN JOURNAL ON ADDICTIONS
fascicolo: 3, volume: 10, anno: 2001,
pagine: 201 - 217
SICI:
1055-0496(200122)10:3<201:MNOA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESOLIMBIC DOPAMINE SYSTEM; DEPENDENT PROTEIN-KINASE; SIGNAL-TRANSDUCTION CASCADE; ELEMENT-BINDING PROTEIN; CHRONIC MORPHINE; LOCUS-COERULEUS; NUCLEUS-ACCUMBENS; ADENYLATE-CYCLASE; PROMOTER ACTIVITY; COCAINE-SEEKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Nestler, EJ Univ Texas, SW Med Ctr, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
E.J. Nestler, "Molecular neurobiology of addiction", AM J ADDICT, 10(3), 2001, pp. 201-217

Abstract

Addiction can be viewed as a form of drug-induced neural plasticity. One of The best established molecular mechanisms of addiction is the upregulation of the cAMP second messenger pathway, which occurs in man, neuronal cell types in response to chronic administration of opiates or other drugs of abuse. This upregulation and The resulting activation of the transcription factor CREB appear to mediate aspects of tolerance and dependence. In contrast, induction of another transcription factor, termed Delta FosB, exerts theopposite effect and may contribute to sensitized responses to drug exposure. Knowledge of these mechanisms could lead to more effective treatments for addictive disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:28:44