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Titolo:
High-salt diet impairs hypoxia-induced cAMP production and hyperpolarization in rat skeletal muscle arteries
Autore:
Frisbee, JC; Sylvester, FA; Lombard, JH;
Indirizzi:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hysiol, Milwaukee, WI 53226 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 281, anno: 2001,
pagine: H1808 - H1815
SICI:
0363-6135(200110)281:4<H1808:HDIHCP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL MASS HYPERTENSION; NITRIC-OXIDE; RESISTANCE ARTERIES; MYOGENIC ACTIVITY; ANG-II; DILATION; PROSTAGLANDINS; ELEVATIONS; RESPONSES;
Keywords:
oxygen; microcirculation; hypoxic dilation; prostacyclin; electrophysiology; autoregulation; vascular reactivity; vascular smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Frisbee, JC Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
J.C. Frisbee et al., "High-salt diet impairs hypoxia-induced cAMP production and hyperpolarization in rat skeletal muscle arteries", AM J P-HEAR, 281(4), 2001, pp. H1808-H1815

Abstract

This study determined the effects of hypoxia on diameter, vascular smooth muscle (VSM) transmembrane potential (E-m), and vascular cAMP levels for invitro cannulated skeletal muscle resistance arteries (gracilis arteries) from Sprague-Dawley rats fed a low-salt (LS) or a high-salt (HS) diet. Arterial diameter and VSM Em were measured in response to hypoxia, iloprost, cholera toxin, forskolin, and aprikalim. In HS rats, arterial dilation and VSMhyperpolarization after hypoxia, iloprost, and cholera toxin were impairedversus responses in LS rats, whereas responses to forskolin and aprikalim were unaltered. Blockade of prostaglandin H-2 and thromboxane A(2) receptors had no effect on responses to hypoxia or iloprost in vessels from both rat groups, suggesting that inappropriate activation of these receptors does not contribute to the impaired hypoxic dilation with HS. Hypoxia, cholera toxin, and iloprost increased vascular cAMP levels in vessels of LS rats only, whereas forskolin increased cAMP levels in all vessels. These data suggest that reduced hypoxic dilation of skeletal muscle microvessels in rats ona HS diet may reflect an impaired ability of VSM to produce cAMP after exposure to prostacyclin.

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Documento generato il 11/07/20 alle ore 20:07:47