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Titolo:
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury
Autore:
Schulman, D; Latchman, DS; Yellon, DM;
Indirizzi:
Univ Coll London Hosp & Med Sch, Hatter Inst Cardiovasc Studies, Div Cardiol, London WC1E 6DB, England Univ Coll London Hosp & Med Sch London England WC1E 6DB C1E 6DB, England Univ Coll London, Inst Child Hlth, London WC1N 1EH, England Univ Coll London London England WC1N 1EH Hlth, London WC1N 1EH, England
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 281, anno: 2001,
pagine: H1630 - H1636
SICI:
0363-6135(200110)281:4<H1630:EOAOTA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE A(1) RECEPTOR; THROMBOLYTIC THERAPY; ADENYLATE-CYCLASE; AGE; MYOCARDIUM; MITOCHONDRIAL; MECHANISM; ACTIVATION; CHANNELS; RECOVERY;
Keywords:
infarct size; adenosine; protein kinase C; ATP-sensitive potassium channels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Yellon, DM Univ Coll London Hosp & Med Sch, Hatter Inst Cardiovasc Studies, Div Cardiol, Grafton Way, London WC1E 6DB, England Univ Coll London Hosp & Med Sch Grafton Way London England WC1E 6DB
Citazione:
D. Schulman et al., "Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury", AM J P-HEAR, 281(4), 2001, pp. H1630-H1636

Abstract

Ischemic preconditioning (IP) reduces infarct size in young animals; however, its impact on aging is underinvestigated. The effect of variations in IP stimuli was studied in young, middle-aged, and aged rat hearts. Isolated hearts underwent 35 min of regional ischemia and 120 min of reperfusion. Hearts with IP were subjected to either one ischemia-reperfusion cycle (5 minof ischemia and 5 min of reperfusion per cycle) or three successive cyclesbefore 35 min of regional ischemia. Additional studies investigated the effects of pharmacological preconditioning in aged hearts using the adenosineA, receptor agonist 2-chloro-N-6-cyclopentyladenosine, the protein kinase C analog 1,2-dioctanoyl-sn-glycerol, and the mitochondrial ATP-sensitive potassium (K-ATP)-channel opener diazoxide. Infarct sizes indicated that the aged rat heart could not be preconditioned via ischemic or pharmacological means. The middle-aged rat heart had a blunted IP response compared with the young adult (only an increased IP stimulus caused a significant reductionin infarct size). These results suggest that there are defects within the IP signaling cascade of the aged heart. Clinical relevance is important if we are to use any IP-like mimetics to the benefit of an aging population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:24:23