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Titolo:
Regulation of myocardial fatty acid oxidation by substrate supply
Autore:
Longnus, SL; Wambolt, RB; Barr, RL; Lopaschuk, GD; Allard, MF;
Indirizzi:
St Pauls Hosp, McDonald Res Labs, iCAPTURE Ctr, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada St Pauls Hosp Vancouver BC Canada V6Z 1Y6 , Vancouver, BC V6Z 1Y6, Canada Univ British Columbia, Dept Pathol & Lab Med, McDonald Res Labs, iCAPTURE Ctr, Vancouver, BC V6Z 1Y6, Canada Univ British Columbia Vancouver BC Canada V6Z 1Y6 ver, BC V6Z 1Y6, Canada Univ Alberta, Cardiovasc Res Grp, Edmonton, AB T6G 2S2, Canada Univ Alberta Edmonton AB Canada T6G 2S2 Grp, Edmonton, AB T6G 2S2, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 281, anno: 2001,
pagine: H1561 - H1567
SICI:
0363-6135(200110)281:4<H1561:ROMFAO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL-COA CARBOXYLASE; 5'-AMP-ACTIVATED PROTEIN-KINASE; WORKING RAT HEARTS; MALONYL-COA; CARNITINE PALMITOYLTRANSFERASE; LIVER-MITOCHONDRIA; CARDIAC MYOCYTES; COENZYME-A; METABOLISM; PHOSPHORYLATION;
Keywords:
heart; acetyl-CoA carboxylase; malonyl; 5 '-AMP-activated protein kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Allard, MF St Pauls Hosp, McDonald Res Labs, iCAPTURE Ctr, Providence HlthCare, Rm 292,1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada St Pauls Hosp Rm 292,1081 Burrard St Vancouver BC Canada V6Z 1Y6
Citazione:
S.L. Longnus et al., "Regulation of myocardial fatty acid oxidation by substrate supply", AM J P-HEAR, 281(4), 2001, pp. H1561-H1567

Abstract

We tested the hypothesis that myocardial substrate supply regulates fatty acid oxidation independent of changes in acetyl-CoA carboxylase (ACC) and 5'-AMP-activated protein kinase (AMPK) activities. Fatty acid oxidation was measured in isolated working rat hearts exposed to different concentrationsof exogenous long-chain (0.4 or 1.2 mM palmitate) or medium-chain (0.6 or 2.4 mM octanoate) fatty acids. Fatty acid oxidation was increased with increasing exogenous substrate concentration in both palmitate and octanoate groups. Malonyl-CoA content only rose as acetyl-CoA supply from octanoate oxidation increased. The increases in octanoate oxidation and malonyl-CoA content were independent of changes in ACC and AMPK activity, except that ACC activity increased with very high acetyl-CoA supply levels. Our data suggestthat myocardial substrate supply is the primary mechanism responsible for alterations in fatty acid oxidation rates under nonstressful conditions andwhen substrates are present at physiological concentrations. More extreme variations in substrate supply lead to changes in fatty acid oxidation by the additional involvement of intracellular regulatory pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:32:57