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Titolo:
Alcohol, antidepressants, and circadian rhythms - Human and animal models
Autore:
Rosenwasser, AM;
Indirizzi:
Univ Maine, Dept Psychol, Orono, ME 04469 USA Univ Maine Orono ME USA 04469 iv Maine, Dept Psychol, Orono, ME 04469 USA
Titolo Testata:
ALCOHOL RESEARCH & HEALTH
fascicolo: 2, volume: 25, anno: 2001,
pagine: 126 - 135
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL CLOMIPRAMINE TREATMENT; LOCOMOTOR-ACTIVITY; SYRIAN-HAMSTERS; RATS; ETHANOL; WITHDRAWAL; PHASE; TEMPERATURE; CONSUMPTION; SECRETION;
Keywords:
circadian rhythm; antidepressants; AOD (alcohol or other drug) use pattern; physiological AODE (effects of AOD use, abuse; and dependence); hypothalamus; CNS (central nervous system) nuclei; brain pathway; serotonin; human study; animal study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenwasser, AM Univ Maine, Dept Psychol, Orono, ME 04469 USA Univ Maine Orono ME USA 04469 sychol, Orono, ME 04469 USA
Citazione:
A.M. Rosenwasser, "Alcohol, antidepressants, and circadian rhythms - Human and animal models", ALCOHOL R H, 25(2), 2001, pp. 126-135

Abstract

Alcohol consumption (both acute and chronic) and alcohol withdrawal have avariety of chronobiological effects in humans and other animals. These effects are widespread, altering the circadian rhythms of numerous physiological, endocrine, and behavioral functions. Thus, some of alcohol's negative health consequences may be related to a disruption of normal physiological timing. Most studies of alcohol's chronobiological effects have been conducted under natural conditions in which environmental stimuli, such as regularcycles of light and darkness, act to coordinate circadian rhythms with theenvironment and with each other. However, such studies cannot distinguish between effects occurring directly on the circadian pacemaker and those occurring "downstream" from the pacemaker on the physiological control systems. Studies using animals have enabled researchers to begin to examine the effects of alcohol on circadian rhythms under so-called free-running conditions in experimental isolation from potential environmental synchronizers. These studies have provided preliminary evidence that alcohol's chronobiological effects are indeed the result of direct influences on the circadian pacemaker itself. Furthermore, the effects of alcohol on animal circadian rhythms appear similar to the effects seen during administration of antidepressant drugs. Taken together with evidence that the chronobiological effects of alcohol withdrawal in human alcoholics are reminiscent of those describedin depressed patients, these observations suggest that alcohol may produceantidepressantlike effects on the circadian pacemaker. One theory suggeststhat the effects of alcohol on the circadian pacemaker are mediated in part by alterations in serotonin, an important chemical involved in cellular communication within the circadian system. However, other neurochemical systems also are likely to be involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:14:23