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Titolo:
Effect of transforming growth factor-beta 1 on the cell growth and Epstein-Barr virus reactivation in EBV-infected epithelial cell lines
Autore:
Fukuda, M; Ikuta, K; Yanagihara, K; Tajima, M; Kuratsune, H; Kurata, T; Sairenji, T;
Indirizzi:
Tottori Univ, Fac Med, Sch Life Sci, Dept Biosignaling, Yonago, Tottori 6838503, Japan Tottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan Natl Canc Ctr, Res Inst, Cent Anim Lab, Tokyo 1040045, Japan Natl Canc Ctr Tokyo Japan 1040045 t, Cent Anim Lab, Tokyo 1040045, Japan Teikyo Univ, Sch Med, Cent Clin Lab, Tokyo 1738606, Japan Teikyo Univ Tokyo Japan 1738606 Med, Cent Clin Lab, Tokyo 1738606, Japan Osaka Univ, Grad Sch Med, Dept Hematol & Oncol, Osaka 5658640, Japan OsakaUniv Osaka Japan 5658640 ept Hematol & Oncol, Osaka 5658640, Japan Natl Inst Infect Dis, Dept Pathol, Tokyo 1628640, Japan Natl Inst Infect Dis Tokyo Japan 1628640 pt Pathol, Tokyo 1628640, Japan
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 288, anno: 2001,
pagine: 109 - 118
SICI:
0042-6822(20010915)288:1<109:EOTGF1>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-CANCER CELLS; TGF-BETA RECEPTOR; CARCINOMA CELLS; REDUCED LEVELS; GENE; PROTEIN; EXPRESSION; LATENT; BINDING; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Sairenji, T Tottori Univ, Fac Med, Sch Life Sci, Dept Biosignaling, Yonago, Tottori 6838503, Japan Tottori Univ Yonago Tottori Japan 6838503 tori 6838503, Japan
Citazione:
M. Fukuda et al., "Effect of transforming growth factor-beta 1 on the cell growth and Epstein-Barr virus reactivation in EBV-infected epithelial cell lines", VIROLOGY, 288(1), 2001, pp. 109-118

Abstract

Transforming growth factor (TGF)-beta1 is a multifunctional cytokine that plays important roles in regulating cell growth and differentiation in manybiological systems. In this study, we found that gastric tissue-derived Epstein-Barr virus (EBV)-infected epithelia[ cell lines GT38 and GT39 had resistance to TGF-beta1-mediated growth inhibition and apoptosis compared to aTGF-beta1 -susceptible gastric carcinoma cell line HSC-39. However, TGF-beta1 partially Induced EBV reactivation In GT38 and GT39 cells, as shown by the Induction of EBV immediate-early BZLF1 RNA and its protein product ZEBRA and early antigen-D. The expressions of TGF-beta receptor I and II were detected in GT38 and GT39 cells by Northern and Western blot analyses. Both cell lines spontaneously produced the TGF-beta1, which was sufficient for inhibiting cell growth of HSC-39 cells. Taken together, these data suggest that TGF-beta1 may be a key factor for EBV reactivation and selective growthof EBV-infected epithelial cells in vivo. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:42:58