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Titolo:
Bronchoconstrictive properties of inhaled 8-epi-PGF(2 alpha) in healthy and heaves-susceptible horses
Autore:
Kirschvink, N; Bureau, F; Art, T; Lekeux, P;
Indirizzi:
Univ Liege, Fac Med Vet, Lab Funct Invest, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 Lab Funct Invest, B-4000 Liege, Belgium
Titolo Testata:
VETERINARY RESEARCH
fascicolo: 5, volume: 32, anno: 2001,
pagine: 397 - 407
SICI:
0928-4249(200109/10)32:5<397:BPOI8A>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; RECURRENT AIRWAY-OBSTRUCTION; IN-VIVO; OXIDATIVE STRESS; ASTHMA; COPD; INFLAMMATION; PONIES; HYPERRESPONSIVENESS; 8-ISOPROSTANE;
Keywords:
pulmonary function tests; heaves in horses; arachidonic metabolites;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kirschvink, N Univ Liege, Fac Med Vet, Lab Funct Invest, Bat B42, B-4000 Liege, Belgium Univ Liege Bat B42 Liege Belgium B-4000 4000 Liege, Belgium
Citazione:
N. Kirschvink et al., "Bronchoconstrictive properties of inhaled 8-epi-PGF(2 alpha) in healthy and heaves-susceptible horses", VET RES, 32(5), 2001, pp. 397-407

Abstract

The 8-epi-PGF(2 alpha) is a marker of oxidative stress which is increased in lungs of asthmatic humans and heaves-susceptible horses. 8-Epi-PGF(2 alpha) has also been demonstrated to be an in vitro and in vivo bronchoconstrictor in humans and rodents. We hypothesised that inhaled 8-epi-PGF(2 alpha)was a bronchoconstrictor in healthy and heaves-susceptible horses in clinical remission. The effect on ventilatory mechanics of nebulised 8-epi-PGF(2alpha) was compared to that of PGF(2 alpha) and U46619, a thromboxane A(2)agonist. Pulmonary resistance (R-L) and dynamic compliance (C-dyn) were assessed in six healthy horses and in six heaves-susceptible horses in clinical remission before (baseline) and immediately after a single inhalation challenge of 1 mg 8-epi-PGF(2 alpha), PGF(2 alpha), or U46619 and placebo. R-L and C-dyn were unchanged after inhalation of 8-epi-PGF(2 alpha) in healthy horses. In heaves-susceptible horses, 8-epi-PGF(2 alpha) induced a significant increase of R-L and a significant decrease of C-dyn when compared to baseline values. Differences between R-L and C-dyn values after 8-epi-PGF(2alpha) inhalation and those of placebo inhalation were not significant. Differences with healthy horses were not significant. PGF(2 alpha) and U46619induced a significant bronchoconstriction in healthy (R-L and C-dyn, versus baseline) and heaves-susceptible horses (R-L and C-dyn, versus baseline and placebo). The R-L increase in heaves-susceptible horses after PGF(2 alpha) inhalation was significantly higher than that in healthy horses. Our results suggest that 8-epi-PGF(2 alpha) is not a bronchoconstrictor in healthyhorses, and a bronchoconstrictor far less efficient than PGF(2)alpha and U46619 at the same dose in heaves-susceptible horses.

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Documento generato il 18/01/20 alle ore 07:32:11